五味子多糖对肝癌小鼠肿瘤生长的抑制作用及其免疫学机理初探  

The Inhibit Effect of Fructus Schizandrae Polysaccharide on the Growth of Tumor in Mice with Hepatocellular Carcinoma and the Primarily Exploring on Immunological Mechanism

作　　者：于赫[1] 李冀[1] 齐彦[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药信息》2010年第2期26-27,共2页Information on Traditional Chinese Medicine

基　　金：黑龙江省博士后科学基金(LBH-Z07002)

摘　　要：目的:明确五味子多糖对小鼠H22肝癌移植瘤的抑制作用,并初步探索其免疫学机理。方法:采用H22荷瘤小鼠,五味子多糖给药1周后称重处死,剥离瘤体,摘取脾脏和胸腺,计算抑瘤率、脾脏指数和胸腺指数。结果:①五味子多糖高、中、低三个剂量组的抑瘤率分别为52.83%、28.54%和22.39%,高、中剂量组与模型组差异分别呈极显著(P<0.01)和显著(P<0.05),低剂量组不显著(P>0.05);②与正常组小鼠相比,模型组小鼠脾脏指数没有显著的改变,胸腺指数显著降低;五味子多糖高剂量组小鼠脾脏指数极显著地高于正常组小鼠和模型组小鼠(P<0.01),胸腺指数与模型组小鼠没有显著区别(P>0.05)。结论:①五味子多糖高、中剂量对小鼠H22肝癌移植瘤具有抑制作用;②五味子多糖高剂量可在器官水平上增强H22荷瘤小鼠的免疫能力,从而起到间接抗肿瘤作用。Objective ： To determinate the inhibit effect of fructus schizandrae polysaccharide on mouse H22 transplanted hepatocellular carcinoma, and tentatively explore the immunological mechanism. Methods：H22 tumor beating mice were weighed and killed after the fructus schizandrae polysaccharide was gave them for 1 week. Then the tumors, spleens and thymus glands were removed to calculate tumor -inhibition rate, spleen index and thymus index. Results ： ①The tumor - inhibition rate of high, moderate and low dose groups of fructus schizandrae polysaccharide treatment was 52.83 % ,28.54% and 22.39%, respectively. The difference between high dose group and moderate group with model group was extremely significant（ P 〈 0. 01 ）and signifi cant （P 〈 0. 05 ）, the low dose group was not significant （P 〉 0.05 ）. ②compared with normal group, there was no significant change on the spleen index of mice in model group, while the thymus index was significant lower. The spleen index of mice in high dose group was extremely significant higher than it in normal group and model gronp（P 〈 0. 01 ）, while there was no significant difference of thymus index with model group（P 〉 0. 05）. Conclusions ： ①High and moderate dose of fructus schizandrae polysaccharide has inhibiting effect on mouse H22 transplanted hepatocellular carcinoma; ②High dose of fructus schizandrae polysaccharide can improve the immune function of H22 tumor - bearing mice on organic level, so as to have indirect anti - tumor effect.

关 键 词：五味子多糖 小鼠 H22 抑瘤率 脾脏指数 胸腺指数 

分 类 号：R285.5[医药卫生—中药学]