2型糖尿病患者精氨酸刺激试验安全性及血钾变化临床观察  

Safety and variation of blood potassium during argentine stimulation test in patients with type 2 diabetes mellitus

作　　者：巫海娣[1] 卞茸文[1] 胡艳[1] 

机构地区：[1]江苏省老年医院内分泌科,江苏省南京市210024

出　　处：《实用老年医学》2010年第2期138-140,共3页Practical Geriatrics

摘　　要：目的观察2型糖尿病(T2DM)患者精氨酸刺激试验过程中的不良反应及试验前后的血钾变化,并探讨精氨酸对受试者血糖的影响,了解精氨酸刺激试验的安全性。方法对70例T2DM患者进行精氨酸刺激试验,同时观察并记录注射精氨酸后受试者对药物的反应及试验前后血糖、血钾的变化。结果静脉快速注射精氨酸后部分患者出现短暂、轻微的口内金属感或舌头短暂发麻、灼热感,但能耐受。所有受试者在注射精氨酸后血糖均有不同程度的升高,但升高幅度不大[ΔPG=(0.46±1.13)mmol/L,P>0.05]。血胰岛素(INS)水平在注射后显著升高[ΔINS=(1.28±0.73)mmol/L,P<0.05],血钾在注射后显著降低[ΔK=-(0.33±0.25)mmol/L,P<0.01],ΔK与空腹血钾呈正相关(r=0.61,P<0.01),而与年龄、肌酐、病程、肾小球滤过率及糖代谢水平均不相关(P>0.05)。结论对于T2DM患者来说,精氨酸刺激试验是安全的,特别是在高血糖患者中应用有优越性。ObjectiveTo evaluate the safety and variation of blood potassium during argentine stimulation test in patients with type 2 diabetes mellitus（T2DM）.MethodsThe argentine stimulation test was performed in 70 individuals with T2DM. The feelings after being injected with argentine of each patient were recorded. Plasma glucose（PG）, insulin and potassium levels were measured.ResultsThe most common feelings included metallic taste, tongue numbness and burning sensation, all of which were tolerable. Plasma glucose increased with no stalistical significance（ΔPG=0.46±1.13 mmol/L,P〉0.05）, while insulin significantly increased（ΔINS=1.28±0.73 mmol/L,P〈0.05）, after injection of argentine. Blood potassium significantly decreased after injection of argentine[ΔK=-（0.33±0.25）mmol/L,P〈0.01]. ΔK was positively correlated to fasting potassium level.ConclusionsIt is safe to conduct argentine stimulation test in patients with T2DM, especially in those with higher blood glucose level.

关 键 词：糖尿病 精氨酸刺激试验 血糖 血钾 

分 类 号：R587.1[医药卫生—内分泌]