双水平气道正压通气对慢性充血性心力衰竭患者氨基末端脑钠肽前体的影响  

Effect of noninvasive positive-pressure respiration on serum N-terminal pro-brain natriuretic peptide in elderly patients with chronic heart failure

作　　者：郭慧峰[1] 杨敬业[1] 张省亮[1] 李胜前[1] 

机构地区：[1]上海交通大学附属第六人民医院老年科,上海市200233

出　　处：《实用老年医学》2010年第2期144-146,共3页Practical Geriatrics

摘　　要：目的探讨双水平气道正压通气对老年慢性充血性心力衰竭病人血浆氨基末端脑钠肽前体(NT-proBNP)水平的影响。方法将120例患者随机分为2组,对照组给予常规抗心衰治疗,治疗组加用双水平气道正压通气(BiPAP)治疗,2组病例均在治疗前、治疗后12h、24h、72h、7d、14d测定血浆NT-proBNP水平,以及评价心衰治疗的效果。结果BiPAP组在治疗后24h起NT-proBNP水平与常规治疗组即有明显差异,治疗组各项指标改善程度优于对照组,2组差异有统计学意义(P<0.01)。结论使用BiPAP可以显著降低老年慢性充血性心衰患者血浆NT-proBNP水平,是治疗心衰的一种安全、可靠的手段。ObjectiveTo investigate the effect of noninvasive positivepressure respiration on serum Nterminal probrain natriuretic peptide （NT-proBNP） in elderly patients with chronic heart failure（CHF）.MethodsOne hundred and twenty patients with CHF were randomly divided into two groups. The control group received only routine treatment, the experimental group received routine treatment, and was also treated with bilevel positive airway pressure ventilation （ BiPAP）. The levels of NT-proBNP were measured before and 12 h, 24 h, 72 h, 7 d and 14 d after the treatment in two groups. The symptoms and physical signs of heart failure were evaluated.ResultsAfter 24hour treatment, the levels of NT-proBNP in the experimental group descended significantly compared with that of control group. Additional improvement was higher in the experimental group compared with the control group. There was significant difference in two groups （ P〈0.01）. ConclusionsApplication of BiPAP respiratory ventilation could decrease the plasma NT-proBNP level in elderly patients with CHF. It is an effective and safe method in treating CHF.

关 键 词：无创正压通气 慢性充血性心力衰竭 氨基末端脑钠肽前体 

分 类 号：R541.61[医药卫生—心血管疾病]