Pd(OAc)_2/TBAB催化卤代芳烃与末端炔烃的Sonogashira交叉偶联反应研究  

Study on the Sonogashira Cross-couplings of Aryl Halides with Terminal Alkynes by Pd(OAc)_2/TBAB

作　　者：陶李明[1] 刘文奇[1] 周芸[1] 

机构地区：[1]湘南学院化学与生命科学系,湖南郴州423000

出　　处：《合成化学》2010年第2期196-199,共4页Chinese Journal of Synthetic Chemistry

基　　金：湖南省自然科学基金资助项目(08JJ3018);湖南省教育厅资助项目(08C828)

摘　　要：研究了无铜、无配体、可回收利用的催化体系[Pd(OAc)2/TBAB]催化卤代芳烃与末端炔烃的Sonogashira交叉偶联反应,高产率地合成了一系列偶联产物,其结构经1H NMR和13C NMR表征。催化实验结果表明,Pd(OAc)2/TBAB可回收重复使用3次,催化活性基本不变。Sonogashira cross-couplings of aryl halides with terminal alkynes were investigated using copper-free, ligand-free and reusable Pd （OAc）2/TBAB as the catalyst. A series of coupling compounds were synthesized in high yields. The structures were characterized by 1^H NMR and 13^C NMR. Pd（ OAc）2/TBAB could be recovered and reused three times without a loss of catalytic efficiency.

关 键 词：溴化四丁基铵 醋酸钯 Sonogashira交叉偶联反应 合成 催化体系 

分 类 号：O643.36[理学—物理化学] O623.225[理学—化学]