Angiostatin抑制转移性肿瘤血管生成的数值模拟  

Numerical Simulation on Inhibitory Effects of Angiostatin on Metastasic Tumor Angiogenesis

作　　者：赵改平[1] 陈二云[2] 沈力行[1] 吴洁[3] 许世雄[3] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海理工大学能源与动力工程学院,上海200093 [3]复旦大学力学与工程科学系,上海200433

出　　处：《计算物理》2010年第2期211-216,共6页Chinese Journal of Computational Physics

基　　金：国家自然科学基金(NO.10772051);上海高校选拔培养优秀青年教师科研专项基金(NO.571215);博士科研启动费基金(NO.10D214)资助项目

摘　　要：针对某些原发性肿瘤能够抑制远处转移性肿瘤快速生长的特性,建立转移性肿瘤附近血管内皮细胞迁移运动的二维、三维离散数学模型,对原发性肿瘤分泌的Angiostatin、转移性肿瘤分泌的促血管生成因子(TAF)共同作用下转移性肿瘤内外微血管网的生成过程进行数值模拟.结果表明,原发性肿瘤分泌的血管抑素对转移性肿瘤内外微血管网的生成速度、成熟度及血管分支数量均有明显的抑制作用;可以降低转移性肿瘤的血管化程度,有效抑制转移性肿瘤的快速生长,达到治疗肿瘤的目的;为肿瘤抗血管生成治疗提供有益信息.We present 2D and 3D discrete mathematical models for migratory response of endothelial cells inside and outside a metastasic tumor based on a physiological fact that some primary tumor can inhibit metastasic tumor growth quickly. In models we consider inhibitory effects of angiostatin excreted by primary tumor, chemotactic effects of TAF due to metastasic tumor and random movement of endothelial cells and simulate spatiotemporal evolution of microvascular network inside and outside the metastasic tumor. It shows that the angiostatin excreted by primary tumor has obviously inhibitory effects on vascular growth rates, bifurcation amount and development of microvascular network inside and outside the metastasic tumor. Inhibitory effects of angiostatin decrease revascularization of a metastasic tumor and suppress growth of the metastasic tumor in tumor therapy. It provides theoretical references for experimental research on clinical anti-angiogenesis.

关 键 词：转移性肿瘤 血管生成 ANGIOSTATIN 抑制效应 数学模型 

分 类 号：R318.01[医药卫生—生物医学工程] TB115[医药卫生—基础医学]