巨噬细胞移动抑制因子与支气管哮喘的关系  

Macrophage migration inhibitory factor associated with bronchial asthma

作　　者：王继旺[1] 张倩[1] 周林福[1] 殷凯生[1] 

机构地区：[1]南京医科大学第一附属医院呼吸科,江苏南京210029

出　　处：《临床肺科杂志》2010年第5期619-620,共2页Journal of Clinical Pulmonary Medicine

基　　金：国家自然科学基金项目(30570797)

摘　　要：目的了解巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)与支气管哮喘的关系。方法应用ELISA法检测了67名支气管哮喘患者和40名健康对照自愿者血清MIF含量并进行比较,同时进行了支气管哮喘患者不同临床分期MIF含量的比较。结果支气管哮喘组血清MIF含量明显高于健康对照组(P<0.05),而在不同临床分期中的含量差异不明显(P>0.05)。结论MIF与支气管哮喘密切相关,与支气管哮喘临床分期无明显关系。Objective To investigate the relationship between maerophage migration inhibitory factor and asthma. Methods Serum MIF levels were measured by an enzyme-linked immunosorbent assay in 40 healthy subjects and 67 asthmatics patients. At the same time the MIF levels in the patients with bronchial asthma at different clinical stages were compared. Results Bronchial asthma serum MIF levels were significantly higher than the control group（ P 〈 0. 05 ）. However the MIF levels at different clinical stages was not obviously different （P 〉 0.05 ）. Conclusion MIF is closely related with bronchial asthma. There is no obvious relationship between MIF and clinical stages of bronchial asthma.

关 键 词：巨噬细胞移动抑制因子 支气管哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]