亚铜催化的碳杂偶联反应机理  

Mechanistic Studies on Cu(Ⅰ) Catalyzed C-X Cross Coupling Reactions

作　　者：于海珠[1] 傅尧[1] 白小宇[1] 郭庆祥[1] 

机构地区：[1]中国科学技术大学化学系,合肥230026

出　　处：《化学进展》2010年第4期557-572,共16页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20972148)资助

摘　　要：近年来,亚铜催化的碳杂偶联反应以其高效、低成本和易制备等优点被广泛研究并应用于工业生产、有机合成及生物活性分子的制备中。目前对于这些碳杂偶联反应机理的探究仍然处于探索性阶段。本文主要评述了近年来亚铜催化的碳杂偶联反应机理的研究进展,重点综述近年来研究相对较多,对机理认识较为完善的碳-氮偶联(特别是酰胺类化合物的芳基化过程),碳氧偶联以及碳硼偶联(不饱和有机化合物的硼化、二硼化反应)机理等方面的进展。最后,基于目前这些机理研究工作的现状,展望了未来机理探究的主要方向。Cu（Ⅰ） catalyzed C-X（X = N,O,S,B…） cross coupling reactions have recently attracted much attention for their great importance in organic synthesis,industrial and biological chemistry.Despite the extensive studies and applications on C-X cross coupling reactions,the mechanisms of these reactions are less well studied.In this work,we mainly review the recent progress in mechanistic studies of the C-X cross coupling reactions,especially the Cu（Ⅰ） catalyzed C-N,C-O cross coupling reactions and the borylation /diborylation reactions of unsaturated organic substrates which are systematically studied recently.Based on the review of the current status of mechanistic studies,we provid some insights and discussion on existing problems and future prospects at last.

关 键 词：亚铜催化 碳-杂偶联 机理 

分 类 号：O621.36[理学—有机化学] O614.121[理学—化学]