过渡金属催化[2+2+2]环加成反应合成吡啶衍生物  

Synthesis of Pyridine Derivatives via Transition Metal-Catalyzed [2+2+2] Cycloaddition

作　　者：王春翔[1] 李新成[1] 徐粉[1] 万伯顺[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116023

出　　处：《化学进展》2010年第4期610-630,共21页Progress in Chemistry

摘　　要：环加成反应可以一步同时构建多个化学键,是目前国内外研究最为活跃的领域之一。相比于传统方法,过渡金属催化的[2+2+2]环加成反应是合成吡啶衍生物的有效手段。本文从反应机理、非手性吡啶化合物合成和手性吡啶化合物合成三个方面阐述了近年来吡啶衍生物的研究情况,涉及Co、Rh、Ru、Fe、Ni、Ti等金属催化体系。Cycloaddition reaction,which can construct several chemical bonds in a single step simultaneously,is one of the most active research fields in organic synthesis.The transition metal-catalyzed [2＋2＋2] cycloaddition reaction is an effective tool for the synthesis of pyridine derivatives comparing with the traditional methods.Recent progress in the synthesis of pyridines is reviewed in this article,involving the reaction mechanism,synthesis of non-chiral pyridines and chiral pyridines.The metal catalytic systems are including Co,Rh,Ru,Fe,Ni,Ti,etc.

关 键 词：吡啶 [2+2+2]环加成 过渡金属催化 炔 腈 

分 类 号：O621.3[理学—有机化学] O626.32[理学—化学]