肝康颗粒对小鼠急性酒精性肝损伤的保护作用  

Protective effects of the Gankang granules on acute alcohol-induced liver injury in mice

作　　者：于海玲[1] 郭建鹏[2,3] 李迎军[1] 张倩[1] 全顺花[1] 李迎春[1] 崔慧艳[1] 

机构地区：[1]延边大学基础医学院机能学实验中心 [2]延边大学药学院药剂学教研室 [3]延边大学长白山生物资源与功能分子教育部重点实验室,吉林延吉133000

出　　处：《延边大学医学学报》2010年第1期13-15,共3页Journal of Medical Science Yanbian University

基　　金：吉林省科技发展计划项目200705422

摘　　要：[目的]探讨肝康颗粒对小鼠酒精性肝损伤的保护作用.[方法]分别灌胃给予不同组的小鼠东宝甘泰及5.85,11.70,23.40 g/kg剂量肝康颗粒,连续5 d,除正常组外其余均灌胃给予500 mL/L乙醇制作小鼠急性酒精性肝损伤模型,禁食不禁水12 h后测定血清丙氨酸转氨酶(ALT)活性、肝组织丙二醛(MDA)及还原型谷胱甘肽(GSH)含量.[结果]肝康颗粒大、中剂量组小鼠肝脏指数及肝组织MDA含量明显降低;肝康颗粒大、中、小剂量组肝GSH活性明显升高,血清ALT活性无显著变化.[结论]肝康颗粒对小鼠急性酒精性肝损伤具有一定的保护作用.OBJECTIVE To study the protective effects of the Gankang granules on alcohol-induced liver injury in mice.METHODSThe Dongbaogantai and 5.85,11.70,23.40g/kg of Gankang granules were performed by intragastric administration in different groups for five days,respectively,and in addition to the normal group,the remaining groups were given by oral administration of ethanol 500mL/L to replicate acute alcohol-induced liver injury model.After absolute diet and no water fasting for 12 hours,the alanine aminotransferase（ALT） in serum,and malondialdehyde（MDA） and reduced glutathione hormone（GSH） content in liver tissue were detected.RESULTSThe liver index and MDA content in liver tissue of mice were obviously decreased in the large and medium dose groups of the Gankang granules,and the content of GSH in liver tissue was increased,but activity of ALT in serum was no changed in the large,medium,and small dose groups of the Gankang granules.CONCLUSIONThe Gankang granules have some protective effects for acute alcoholic liver injury in mice.

关 键 词：中成药 酒精中毒 肝疾病 小鼠 

分 类 号：R285.5[医药卫生—中药学]