大鼠再生肝8种细胞的基因转录谱预示BE115434和X76129参与凝血反应  

Gene Transcript Profiles of Liver Cells Predicted that X76129 and BE115434 Participate in Blood Coagulation in Rat Regenerating

作　　者：高静[1,2] 常翠芳[1,2] 徐存拴 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007 [2]河南省-科技部共建细胞分化国家重点实验室培育基地,河南新乡453007

出　　处：《河南科学》2010年第4期410-414,共5页Henan Science

基　　金：国家973项目前期研究专项(2006CB708506)

摘　　要：为了解新基因BE115434和X76129与大鼠再生肝的凝血反应相关性,按张丽君[1]等方法分离大鼠再生肝8种细胞、检测它们的基因表达变化,分析新基因的序列同源性、共表达关系及参与的生理活动.结果表明,X76129与纤溶酶原激活酶基因plaur同源和共表达,BE115434与纤维蛋白活化因子抑制蛋白serpind1同源和共表达.它们的表达变化预示X76129和BE115434参与大鼠再生肝的凝血反应.To explore the correlation regenerating, isolation of rat 8 liver cell to the method described by Zhang et al. of new genes BE115434,X76129 with blood coagulation in rat liver types, and detection of gene expression change were performed according And the genes sequence homology and co-expression relation, the possible physiological activities were analyzed. It was found that X76129 and plaur which involved in profibrinolysin activating were homologous and co-expressed, and also was BE115434 and serpindl which involved in inhibiting fibrin activation. Their expression change predicted X76129 and BE115434 participate in blood coagulation in rat regenerating.

关 键 词：大鼠肝再生 Rat GENOME 230 2.0芯片 基因表达谱分析 凝血反应 

分 类 号：Q418[生物学—生理学]