HBV感染对肝移植术后巨细胞病毒感染的影响  

The correlation of HBV infection and HCMV reactive infection after liver transplantation

作　　者：赵宏[1] 范骏[1] 胡建华[1] 高海女[1] 杨美芳[1] 张旋[1] 周琳[2] 马伟杭[1] 

机构地区：[1]浙江大学医学院附属第一医院传染病研究所传染病诊治国家重点实验室,杭州310003 [2]浙江大学附属第一医院卫生部多器官联合移植重点实验室

出　　处：《中华微生物学和免疫学杂志》2010年第2期150-153,共4页Chinese Journal of Microbiology and Immunology

基　　金：国家973项目（2007CB513005）;国家自然科学基金（30471631,30872239）;国家重点实验室自主课题（2008ZZ05）;浙江省卫生厅基金（2007A058）

摘　　要：目的 探讨肝移植患者移植术前后HBV感染对移植术后巨细胞病毒（CMV）感染及其肝功能的影响.方法 回顾性分析我院近两年来113例肝移植患者临床资料,排除术后1月内死亡、血型不符、失访和并发其他噬肝病毒感染患者,共有102例患者纳入.根据肝移植术前是否感染HBV将患者分为HBV感染组和对照组（非HBV感染）;对于感染组患者,又根据移植术后HBV是否复发分为术后复发组和非复发组,采用免疫组化方法 检测CMV被膜抗原pp65水平,时间分辨法检测乙肝病毒抗原和抗体水平,常规方法 检测肝转氨酶水平.结果 HBV感染组（n=83）和对照组（n=19）中,术后pp65阳性率分别为84.3%（70/83）和57.9%（11/19）（P=0.024）;HBV感染组中,HBV复发组和非复发组中pp65阳性率分别为90.9%（10/11）和83.3%（60/72）（P=0.843）,各组间肝转氨酶水平差异无统计学意义（P〉0.05）.结论 肝移植术前HBV感染可以增加术后CMV病毒血症风险,而肝移植后HBV复发并不增加CMV病毒血症风险;同时,与单一HBV或CMV感染而言,两种病毒联合感染并不明显引起肝转氨酶水平的升高.Objective To study the correlation of HBV infection pretransplantation and posttrans-plantation and HCMV recurrence after liver transplantation （LT）. Methods We reviewed historical patient medical records of LT patients in recent two years in our hospital. All the patients were divided into HBV in-fection group and a control group based on a peripheral blood HB antigen assay before LT. The HBV infec-tion group was divided into HBV reactive infection group and HBV non-relapse group. HCMV antigen pp^65 was detected by immunohistochemical methods. HB antigens and antibodies were detected by time-resolved fluorescence immunoassay, and liver enzyme levels were detected by conventional methods. Results Com-paring two groups of patients, pp65-positive rates of LT patients with HBV infection and control group pa-tients were 84.3% and 57.9% respectively （P=0.024）. While in HBV recurrence infection group and non-recurrence infection group, the incidences of HCMV recurrence were 90.9% and 83.3% （P=0.843）. The changes in the liver transaminases level in both groups have no statistical significance （P〉0.05）. Conclusion Pretransplantation HBV infection may increase the incidence of HCMV recurrence. Posttrans-plantation HBV reactive infection, however, may not increase the incidence of HCMV reactive infection. Meanwhile, compare with either HBV infection or HCMV infection alone, co-infection may not serious in liv-er enzymes levels.

关 键 词：乙肝病毒 肝移植 巨细胞病毒 转氨酶 

分 类 号：R657[医药卫生—外科学]