鱼腥草注射液体内抗流感病毒药效学研究  

Pharmacodynamic experiment of the antivirus effect of Houttuynia Cordata Injection on influenza virus in mice

作　　者：刘方舟[1,2] 时瀚[1] 时宇静[1] 刘颖[1] 金亚宏[1] 高英杰[1] 郭姗姗[1] 崔晓兰[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]江西中医学院,江西南昌330004

出　　处：《药学学报》2010年第3期399-402,共4页Acta Pharmaceutica Sinica

基　　金：科技部甲型H1N1流感联防联控应急科研项目

摘　　要：本研究评价新、老两种鱼腥草注射液制剂在体内对H1N1流感病毒感染的防治作用。采用甲型H1N1流感病毒FM1和PR8株,滴鼻感染正常小鼠和免疫低下小鼠造成肺炎模型,分别进行治疗性和预防性给药,观察小鼠肺指数。结果显示:鱼腥草注射液新、老两种制剂对两种流感病毒感染引起的小鼠肺部炎症均有明显治疗作用,且小剂量时新制剂对FM1株治疗作用优于老制剂;新、老两种制剂对两种病毒感染免疫低下小鼠引起的肺部炎症有明显预防作用,且小剂量时老制剂对PR8病毒株的预防作用优于新制剂。鱼腥草注射液可改善流感病毒引起的小鼠肺炎症状,降低H1N1感染小鼠的肺指数,在体内对H1N1流感病毒感染有较好的防治作用。It is to investigate the effect of two kinds of Houttuynia Cordata Injection on preventing and treating H1N1 influenza virus infection in mice. Pneumonia model was set up by intranasal infection of the normal and immunocompromised mice with influenza virus FM1 and PR8. The two injections were administered before and after the administration of virus, separately, and the lung index was observed. The results showed that the two preparations have obvious therapeutic effect on normal mice infected with influenza virus FM1 and PR8. And to FM1, the new injection’s effect is better at small dosage. The results also showed that the two preparations have obvious prophylactic effect on immunodepressed mice infected with influenza virus FM1 and PR8. And to PR8, the old injection’s effect is better at small dosage. Houttuynia Cordata Injection can improve the mice pneumonia caused by influenza virus H1N1 and decrease the lung index markedly. It has a remarkable preventive and therapeutic effect on H1N1 influenza virus in mice.

关 键 词：FM1毒株 PR8毒株 甲型流感病毒H1N1 鱼腥草注射液 

分 类 号：R965[医药卫生—药理学]