电针“神门”“太溪”穴对急性心肌缺血家兔心交感神经电活动的影响  

Effects of Electroacupuncture of "Shenmen" (HT 7) and "Taixi" (KI 3) on Cardiac Sympathetic Activities in Acute Myocardial Ischemia Rabbits

作　　者：吴子建[1] 蔡荣林[1] 龙迪和[1] 何璐[1] 胡玲[1] 

机构地区：[1]安徽中医学院针灸经络研究所,合肥230038

出　　处：《针刺研究》2010年第1期32-36,共5页Acupuncture Research

基　　金：国家自然科学基金青年科学基金(30801484)

摘　　要：目的:通过观察电针"神门""太溪"穴对急性心肌缺血家兔心交感神经电活动的影响,研究电针同名经穴对急性心肌缺血作用的相对特异性。方法:随机选择8只家兔作为正常组,余家兔经股静脉注射垂体后叶素3 U/kg复制急性心肌缺血模型。将模型复制成功的家兔随机分为模型组、"神门"组、"太溪"组和非经穴组,每组8只。各电针组刺激电流为1.1 mA,频率为2 Hz,每次刺激10 min,进行电针治疗。采用BIOPAC生物信号采集系统观察各组家兔30 min内心率和交感神经活动变化情况。结果:急性心肌缺血模型复制后,心率明显下降、心交感神经电活动的频率一过性增多后急剧减少,与正常组家兔比较差异有统计学意义(P<0.01)。在停针即刻,"神门"组家兔的心率和心交感神经电活动的频率与模型组比较显著增高(P<0.01);"太溪"组及非经穴组家兔心率和心交感神经电活动的频率与模型组比较差异无统计学意义(P>0.05),与正常组比较显著降低(P<0.01)。在20 min时刻,"神门"组家兔的心交感神经电活动频率高于模型组(P<0.01),与正常组家兔比较差异无统计学意义(P>0.05);"太溪"组与非经穴组家兔的心交感神经电活动频率与模型组比较差异无统计学意义(P>0.05),与正常组比较显著下降(P<0.01)。结论:电针不同经穴对急性心肌缺血家兔的调整作用存在一定的相对特异性,电针心经原穴"神门"的调整效应优于其同名经原穴"太溪"。Objective To observe the effect of electroacupuncture （EA） of different acupoints on activities of the cardiac sympathetic nerve in rabbits with acute myocardial ischemia （AMI）. Methods A total of 40 Chinchilla rabbits were randomized into normal control, model, Shenmen （HT 7）, Taixi （KI 3） and non-acupoint groups （n = 8/group）. AMI model was established by intravenous injection of pituitrin （3 U/kg）. EA （1. 1 mA, 2 Hz） was applied to bilateral HT 7, KI 3 and non-acupoint （the bulge site of the triangular muscle） for 10 min. The rabbit＇s cardiac sympathetic discharges were recorded by BIOPAC under anesthesia. Results In comparison with control group, the heart rate （HR） and the frequency of cardiac sympathetic discharges （CSD） decreased significantly after AMI （ P〈0.01 ）. At the moment of cease of EA, at 20 min after EA, HR and CSD frequency in HT 7 group were significantly higher than those of model group （P〈0.01）, suggesting a favorable inhibition of EA of HT 7 on the decreased HR and CSD. No significant differences were found between KI 3 and model groups, and between KI 3 and non-acupoint groups in both HR and CSD at any time courses （ P〉0.05）. Conclusion EA of HT 7 can correct AMI-induced decrease of both HR and CSD in the rabbit, while EA of KI 3 and non-acupoint have not this effect, suggesting a relatively specific efficacy of EA of different acupoints on cardiac sympathetic activities.

关 键 词：急性心肌缺血 心交感神经活动 电针 神门 太溪 

分 类 号：Q424[生物学—神经生物学]