槲皮黄素灌胃后大鼠肝静脉血浆代谢组学的变化及其意义  

Analysis of metabonomic changes of hepatic vein plasma after oral administration of quercetin in rats

作　　者：安代志[1] 张琪[2] 韦京豫[1] 杨继军[1] 颜贤忠[2] 郭长江[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所,天津300050 [2]国家生物医学分析中心,北京100850

出　　处：《肠外与肠内营养》2010年第2期85-88,共4页Parenteral & Enteral Nutrition

基　　金：国家自然科学基金资助项目(30571567)

摘　　要：目的:研究槲皮黄素灌胃后对大鼠肝静脉血浆代谢组学的变化及其意义。方法:大鼠按40mg/kg剂量槲皮黄素灌胃,分别于灌胃前(0h)、灌胃后0.5、1、2和4h采集肝静脉血液制备血浆,以1H核磁共振(1H NMR)分析代谢组变化。结果:槲皮黄素灌胃后,大鼠肝静脉血浆代谢组呈聚类分布,葡萄糖含量下降,β-羟丁酸、琥珀酸和丙酮酸等水平升高。结论:槲皮黄素对大鼠肝代谢具有显著影响,主要表现为葡萄糖分解增强,酮体生成增加。Objective：To investigate the effects of quercetin on hepatic vein metabolic profiles in rats. Methods： Male Wistar rats were administrated orally with 40 mg/kg quercetin. Hepatic vein plasma was collected at 0 h, 0.5 h, 1 h, 2 h and 4 h respectively after administration and analyzed by 1H NMR. Results：The identifiable biochemical effects associated with quercetin dosing included decreased plasma concentration of glucose and increased plasma concentration of succinate,β-hydroxybutyrate and pyruvate. Conclusion： Quercetin changes hepatic metabolism in rats, manifested mainly as increased glucose catabolism and production of ketone bodies.

关 键 词：槲皮黄素 代谢组学 核磁共振 

分 类 号：R285.5[医药卫生—中药学]