不同粒径和浓度超顺磁性氧化铁MR信号特征的实验研究  

Magnetic resonance signal features of superparamagnetic iron oxide with different partical size and concentration

作　　者：林冰影[1] 张景峰[1] 张敏鸣[1] 

机构地区：[1]浙江大学医学院附属第一医院放射科,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2010年第2期125-129,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：国家高技术研究发展计划(863计划)资助项目(2006AA02Z485);浙江省科学技术厅重大与高发疾病防治技术专项基金(2008C13027-2);浙江省自然科学基金(J20060714);浙江省医药卫生优秀青年科技人才专项基金(2009QN009);浙江省中医药青年课题资助项目(2007YB032)

摘　　要：目的:研究超顺磁性氧化铁(superparamagnetic iron oxide,SPIO)对周围质子的弛豫时间的影响,探讨不同颗粒、浓度SPIO的MR信号特征。方法:对不同粒径及浓度的SPIO颗粒进行磁共振扫描,记录各个粒径和浓度的SPIO颗粒的MR T1、T2、T2*值,评价其信号特征。结果:①不同粒径的SPIO颗粒T1值与浓度呈负相关线性关系;②当SPIO浓度较低时,随粒径减小T2和T2*值则上升明显;当SPIO浓度较高时,随粒径减小上升渐趋缓慢;③lg(T2)与SPIO颗粒粒径和浓度之间存在线性依存关系。结论:SPIO颗粒对MR信号的影响以T1和T2效应为主;T2值可作为SPIO颗粒MR成像的主要检测指标;SPIO粒径大小、浓度和T2值三者之间存在着特定的线性关系。Objective： To investigate the magnetic resonance（MR） signal features of superparamagnetic iron oxide（SPIO） with different partical size and concentration.Methods： The superparamagnetic iron oxide with different concentration and particle size was scanned by magnetic resonance;T1,T2 and T2＊ values of each group were recorded to evaluate the features of MR signals.Results： The T1 value of SPIO with different particle size had negative linear relationship with concentration.In low concentration the T2 and T2＊ values were elevated markedly with the particle size decreased;while in high concentration the T2 and T2＊ values were elevated gently with particle size decreased.lg（T2）,particle size and concentration of SPIO had linear relationship.Conclusions： SPIO affects magnetic resonance signal mainly with effect on T1 and T2.T2 value can be regarded as the major detection index in the magnetic resonance scan of SPIO.There is a linear relationship among particle size,SPIO concentration and lg（T2） value.

关 键 词：磁共振成像 铁化合物/投药和剂量 超顺磁性氧化铁 弛豫时间 信号特征 

分 类 号：R445.2[医药卫生—影像医学与核医学]