JMJ14 is an H3K4 demethylase regulating flowering time in Arabidopsis  

作　　者：Falong Lu Xia Cui Shuaibin, Zhang Chunyan Liu Xiaofeng Cao 

机构地区：[1]National Key Laboratory of Plant Genomics and Center forPlant Gene Research, Institute of Genetics and DevelopmentalBiology, Chinese Academy of Sciences, No. 1, Bei Chen WestRoad, Chaoyang District, Beijing 100101, China [2]Graduate School, Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Cell Research》2010年第3期387-390,共4页细胞研究（英文版）

基　　金：We thank Dr T Jenuwein for providing us the H3K27me3 antibody and Qingbao Zhu for technical support. We thank the Arabidopsis Biological Resources Center at Ohio State for providing SALK T-DNA-insertion lines. This work was supported by grants from the National Basic Research Program of China （2009CB941500 and 2005CB522400 to XC） and the National Natural Science Foundation of China （30771209 to CL, and 30930048 and 30921061 to XC）.

摘　　要：Histone lysine methylation plays an essential role in regulating chromatin functions such as transcription and heterochromatin formation. Histone H3 lysine 4 （H3K4） methylation is linked to active transcription [1, 2]. Recent findings in mammals have demonstrated that histone methylation is reversible by a family of Jumonji C （JmjC） domain-containing proteins. KDM5/ JARID1 family proteins have been shown to be able to demethylate H3K4mel,2,3 in mammals [3]. Previously, we identified six proteins in Arabidopsis showing high sequence similarity to KDM5/JARIDI family proteins [4]. Here we demonstrate that one such protein, JMJ14, is an active histone H3K4 demethylase and is involved in flowering time regulation.

关 键 词：开花时间 拟南芥 组蛋白甲基化 组蛋白H3 蛋白质家族 调控 转录活性 哺乳动物 

分 类 号：Q943[生物学—植物学] S682.11[农业科学—观赏园艺]