毛囊干细胞标记物的研究进展  

Progress in Markers of Hair Follicle Stem Cells

作　　者：倪振洪[1,2] 邵勇[1,2] 李玉红[1,2] 

机构地区：[1]第三军医大学学员旅一队,重庆400038 [2]第三军医大学基础部细胞生物学教研室,重庆400038

出　　处：《中国细胞生物学学报》2010年第1期43-48,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30671888)~~

摘　　要：毛囊干细胞是一类位于毛囊隆突区的成体干细胞,对毛囊的周期性生长,表皮和皮脂腺的更新以及皮肤损伤后修复有着至关重要的作用。毛囊干细胞的标记物是对毛囊干细胞进行分离和鉴定的重要依据,对毛囊干细胞的基础研究起着关键作用。因此寻找特异性较高的毛囊干细胞标记物成为了近年的研究热点。本文按毛囊干细胞标记物在细胞中所处部位进行分类,将其分为位于细胞膜、细胞质、细胞核的标记物,综述了目前国内外主要采用的整合素、角蛋白、CD34、CD200等标记物以及新发现的Lgr5、Sox9、Tcf3等基因标记物。Hair follicle stem cells （FSCs） located in the hair follicle bulge region are a group of adult stem cells which play a key role in periodic growth of hair follicle, renewal of epidermis and sebaceous gland and skin repair after injury. The markers of FSCs are necessary for the identification and separation of FSCs and critical for the basic research of FSCs. To find the better markers of FSCs has become a study hotspot in recent years. In this review we classify the makers to three types according to their distinct locations in the cells, one in the cell membrane, one in the cytoplasm and one in the nucleus. We focus on the frequently used markers such as integrin, keratin, CD34, CD200 and also introduce some novel ones including Lgr5, Sox9, Tcf3, and so on.

关 键 词：毛囊干细胞 标记物 隆突区 

分 类 号：Q25[生物学—细胞生物学]