应用基因芯片技术探讨载脂蛋白E基因多态性与脑白质疏松的关系  

Association of apolipoprotein E gene polymorphism with leukoaraiosis

作　　者：孟宜良[1] 贺超奇[2] 戴月红[1] 胡文宏[1] 宣海仙[1] 金扬[1] 

机构地区：[1]杭州市萧山区第一人民医院神经内科,311201 [2]杭州市萧山区第一人民医院中心实验室,311201

出　　处：《浙江医学》2010年第3期353-354,358,共3页Zhejiang Medical Journal

摘　　要：目的探讨用基因芯片技术检测载脂蛋白E基因的可行性，研究载脂蛋白E基因多态性与脑白质疏松症的关系。方法分别对204例脑CT或MRI检查确诊的脑白质疏松症患者（LA组）和180例脑CT或MRI正常者（对照组）。应用基因芯片技术进行载脂蛋白E基因多态性检测。结果LA组ApoEE2、E3和ε4等位基因频率分别为0．078、0．745、0．186，对照组等位基因频率分别为0．088、0844、0．066，LA组ApoEE4基因频率显著高于对照组，差异有统计学意义（P〈0．05），而ApoE￡3及ApoEE2基因频率两组与对照组比较差异无统计学意义。结论ApoEE4等位基因与脑白质疏松有关，ApoE4等位基因可能是脑白质遗传易患标志之一。Objective To investigate the association of apolipoprotein E gene polymorphism with leukoaraiosis. Methods Two hundred and four patients with leukoaraiosis, which was confirmed by CT or/and MRI scan, and 180 normal subjects were enrolled in the study. The polymorphism of apolipoprotein E gene was detected by gene chip technique. Results The frequency of ApoE E 4 allele in the leukoaraiosis group was significantly higher than that in the control group （0.186 vs 0.066, P〈0.05）. Conclusion ApoE E 4 allele is associated with leukoaraiosis and it may be used as a predictor for susceptibility of white matter damage.

关 键 词：载脂蛋白E基因 基因芯片 脑白质疏松 

分 类 号：R587.2[医药卫生—内分泌]