国产苯溴马隆治疗青年高尿酸血症的临床观察  

Clinical Efficacy of Domestic Benzbromarone in the Treatment of Hyperuricemia in the Youth

作　　者：刘志新[1] 林振[1] 蓝宇[1] 马育林[1] 韦海潮 廖国柱 

机构地区：[1]广东中山市小榄人民医院,中山市528415

出　　处：《中国药房》2010年第12期1117-1118,共2页China Pharmacy

摘　　要：目的:观察国产苯溴马隆治疗青年高尿酸血症的临床疗效及安全性。方法:113例青年高尿酸血症患者随机分为2组:对照组55例,给予低嘌呤饮食治疗;治疗组58例,在对照组基础上,加服国产苯溴马隆50mg,qd。4周后测定血尿酸含量和相关指标。结果:治疗组总有效率(84.48%)高于对照组(41.82%),差异有统计学意义(P<0.01);治疗后治疗组的血尿酸、尿素氮、肌酐、微量白蛋白尿较对照组有显著改善,差异有统计学意义(P<0.01或P<0.05);2组治疗前后在血常规和肝功能方面则无显著性差异(P>0.05);试验中2组均未见明显不良反应。结论:国产苯溴马隆对青年高尿酸血症有较好的治疗作用,且不良反应少。OBJECTIVE： To investigate the clinical efficacy and safety of domestic benzbromarone in treatment of hyperuricemia in the youth. METHODS： 113 young patients with hyperuricemia were randomly divided into treatment group（n = 58） and control group（n=55）. Both groups were given low purine diet for four weeks. Treatment group were additionally treated with domestic benzbromarone 50 mg once a day. The level of blood uric acid and related indicators were tested at the end of the treatment. RESULTS： The total effective rates were 84.48% for treatment group and 41.82% for control group, Statistical significance was noted in clinical efficacy between two groups （P〈0.01）. The decrease of blood uric acid level in treatment group was more significant than in control group（P〈0.01）. The urea nitrogen, creatinine and microalbuminuria in treatment group were promoted significantly, which was significantly different from in control group（P〈0.01 or P〈0.05）. There were no significant differences between two groups regarding to blood count and liver function（P〉0.05） ;2 group had no significant adverse reaction. CONCLUSION： Domestic benzbromarone has good therapeutic effect and no significant adverse reaction on hyperuricemia in youth.

关 键 词：苯溴马隆 高尿酸血症 青年 

分 类 号：R589.7[医药卫生—内分泌]