丙氨酸氨基转移酶不合格献血者中不同区段丙型肝炎病毒抗体的筛查  

Antibody detecting against different function regions of HCV in high ALT level blood donors

作　　者：安媛[1,2] 修冰水[3] 章金刚[1] 张烨[2] 张向颖[4] 邱艳[2] 

机构地区：[1]军事医学科学院野战输血所,北京100850 [2]北京市红十字血液中心 [3]军事医学科学院基础医学研究所 [4]中国药品生物制品检定所

出　　处：《北京医学》2010年第4期323-325,共3页Beijing Medical Journal

基　　金：国家863目标导向课题(2008AA02Z434);"十一五"国家科技重大专项(2008ZX10002-013);北京市自然科学基金(7082048)

摘　　要：目的探讨丙氨酸氨基转移酶(ALT)不合格献血者丙型肝炎病毒不同功能区抗体的检出情况。方法收集献血前乙型肝炎表面抗原(HBsAg)和ALT筛查中ALT不合格的血清样本,采用融合F4HVR1抗原检测样本中的第1高变区(HVR1)抗体,并与现有的C、NS3、NS4、NS5区抗体进行比较。结果在2035份ALT不合格样本中,共检测出34份阳性样本,其中HVR1区单独阳性2份,C区3份,NS3区4份,NS5区1份。结论丙型肝炎病毒各区段抗体筛查对提高输血安全性具有积极的作用。Objective To screen the antibodies against different function regions of hepatitis C virus （HCV） in blood donors with high ALT level. Methods The selected blood samples were collected from blood donors. The HCV antibodies were detected by F4HVRl antigen, and to compared with antibodies against HCV Core、NS3、NS4、NS5. Results Among all the 2035 samples with high ALT level,34 were antibodies positive, two were only positive for HVR1,three were only positive for Core, four were only positive for NS3, one were only positive for NS5. Conclusions The detection of different function region antibodies is helpful in improving blood transfusion safety.

关 键 词：丙型肝炎病毒 第1高变区 抗体 安全输血 

分 类 号：R446.6[医药卫生—诊断学]