树枝状聚合物聚酰胺-胺作为药物载体应用研究进展  

Progress in application of dendrimer polyamidoamine as drug carrier

作　　者：姚文军[1] 孙考祥[1] 

机构地区：[1]烟台大学药学院,烟台264005

出　　处：《中国新药杂志》2010年第6期494-497,共4页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30873447)

摘　　要：树枝状聚合物聚酰胺-胺(PAMAM)是一种三维的、高度枝化的树枝状高分子,具有单一分散性、无免疫原性、细胞毒性较低、生物可降解等特性,目前作为药物载体在药学领域引起了高度关注。文中分别综述了其载药机制及其在静脉、口服、经皮、眼部等不同给药途径的应用研究进展。研究发现其载药机制主要为物理包埋载药与静电、共价结合载药。PAMAM作为药物载体能够增加药物的溶解度,不同途径给药后能延缓药物的释放,增加药物皮肤渗透系数,延长角膜滞留时间,从而增加药物的生物利用度,是一种颇具发展潜力的新型药物载体。Dendrimer polyamidoamine（PAMAM） is a hyperbranched and three dimensional macromolecule which possesses properties of monodispersion,non-immunogenicity,low cytotoxicity and biodegradation.Recently,as drug carrier,it has been paid more attention in pharmaceutical science.In this review,we described drug loading mechanisms as well as the applications of dendrimers in different drug administration routes such as vein injection,oral administration,transdermal delivery,ocular delivery and so on.It has been found that the drug loading mechanisms are physical encapsulation and electrostatic interaction,covalent combination.PAMAM as drug carrier could increase the solubility of the drug,delay drug release,increase the skin permeability coefficient,prolong the residence time in cornea and increase the bioavailability of the drug.It might be a potential and novel drug carrier.

关 键 词：树枝状聚合物 树枝状聚合物聚酰胺-胺(PAMAM) 药物载体 载药机制 给药途径 

分 类 号：R95[医药卫生—药学]