羟基喜树碱磷脂复合物的溶解性考察与表征  

Liposolubility investigation and characterization of hydroxycamptothecin phospholipid complex

作　　者：贺小玲[1] 苏冰[2] 王东凯[1] 李翔[1] 肖玉婷[1] 冷迪[1] 王雪丽[3] 

机构地区：[1]沈阳药科大学药学院,沈阳110016 [2]白求恩医科大学制药厂,长春130012 [3]沈阳军区总医院肾内科,沈阳110016

出　　处：《中国新药杂志》2010年第6期541-543,547,共4页Chinese Journal of New Drugs

摘　　要：目的:制备羟基喜树碱磷脂复合物,进行溶解度考察和表征,推测其形成机理并为下一步的制剂制备提供参考。方法:以四氢呋喃为复合溶剂制备羟基喜树碱磷脂复合物,考察磷脂复合物在正辛醇与氯仿2种溶剂中的溶解性能,并采用紫外(UV)、红外(IR)与差示扫描量热法(DSC)对复合物进行表征。结果:羟基喜树碱磷脂复合物在氯仿中的溶解度显著提高但不稳定。紫外、红外图谱与DSC结果验证了复合物的形成。结论:羟基喜树碱可能与磷脂的极性端复合形成复合物,药物的脂溶性与溶出速率得以提高。Objective：To prepare and characterize hydroxycamptothecin（HCPT） phospholipid complex with high liposolubility compared with HCPT.Methods：Tetrahydrofuran was used as complex solvent to prepare HCPT phospholipid complex.The ultraviolet spectroscopy,infrared spectroscopy and differential scanning calorimetry were adopted to characterize HCPT phospholipid complex.The solubility of HCPT phospholipid complex in octanol and chloroform were investigated.Results：Infrared spectroscopic and DSC analysis proved the formation of the phospholipid complex.The solubility of the complex was significantly improved but unstable in chloroform.Conclusion：HCPT was complex with the polarized end of lecithin.The liposolubility and dissolved rate were improved.

关 键 词：羟基喜树碱 磷脂复合物 紫外分光光度法 红外光谱法 差示扫描量热法 

分 类 号：R943[医药卫生—药剂学] R979.1[医药卫生—药学]