LC-MS法测定抗风湿类中药非法添加化学药物成分  

Determination of Chemical Components Illegally Mixed in Antirheumatic Traditional Chinese Medicine by LC-MS

作　　者：来国防 程宾 鲁静[2] 

机构地区：[1]云南省食品药品检验所,昆明650011 [2]中国药品生物制品检定所

出　　处：《中国药师》2010年第4期453-455,共3页China Pharmacist

基　　金：国家科技支撑计划项目(No.2006BAI14803-2);云南省技术创新人才培养对象第九批(2009CI107)

摘　　要：目的:建立快速、准确、高灵敏度的测定抗风湿类中药制剂中非法添加对乙酰氨基酚、甲氧苄啶、吡罗昔康、萘普生、保泰松分析方法。方法:采用HPLC-DAD、UPLC/MS/MS法对非法掺入的化学药物进行定性鉴别,并以HPLC测定含量。结果:受试制剂中检测到掺有对乙酰氨基酚、吡罗昔康、萘普生。结论:此方法灵敏准确,可作为抗风湿类中药制剂中非法添加对乙酰氨基酚、甲氧苄啶、吡罗昔康、萘普生、保泰松的有效检测方法。Objective： To establish a quick, accurate, sensitive method for analysis of 4-acetamidophenol, trimethoprim, piroxicam, naproxen and phenylbutazone illegally mixed in Antirheumatic traditional Chinese medicine （TCM）. Method： Five Chemieal compo- nents in TCM preparation were separated, identified and determined by HPLC-DAD and UPLC/MS/MS. Result： 4-Acetamidophenol, piroxieam and naproxen were found in formulationgs. Condusion： The method is sensitive and accurate, and can be used to detect the 4-aeetamidophenol,trimethoprim, piroxieam, naproxen and phenylbutazone illegally mixed in Antirheumatie traditional Chinese medicine.

关 键 词：高效液相色谱法 超高效液质联用仪 抗风湿类中药制剂 对乙酰氨基酚 甲氧苄啶 吡罗昔康 萘普生 保泰松 

分 类 号：R917[医药卫生—药物分析学]