糖痹康对糖尿病周围神经病变大鼠坐骨神经传导速度的影响  

Effects of Tang Bi Kang on Sciatic Nerve Conduction Velocity in Rats of Diabetic Peripheral Neuropathy

作　　者：王佳[1] 刘铜华[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中医基础医学杂志》2010年第3期209-211,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家科技重大新药创制专项-治疗糖尿病周围神经病变候选药物糖痹康研究(2009ZX09103-303)

摘　　要：目的:探讨糖痹康对链脲佐菌素(Streptozotocin,STZ)诱导的糖尿病周围神经病变(Diabetic penipheral neuropathy,DPN)大鼠坐骨神经传导速度的影响。方法:腹腔注射STZ55mg/kg建立糖尿病大鼠模型,分为正常组、模型组、弥可保组、糖痹康小剂量组、糖痹康中剂量组、糖痹康大剂量组。12周后处死大鼠,常规坐骨神经HE染色,测定右侧体表和体内坐骨神经运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)。实验数据用SPSS16.0进行统计学处理。结果:坐骨神经组织病理学检查显示,糖痹康组坐骨神经病理学改变较模型组轻。与模型组比较,糖痹康组中、高剂量组坐骨神经MNCV、SNCV显著加快(P<0.01),糖痹康组中、高剂量组运动和感觉坐骨神经1.5倍阈刺激诱发的动作电位幅度明显加大(P<0.01)。结论:糖痹康能改善STZ诱导的DPN坐骨神经传导速度减慢及其动作电位的减小,且其对神经传导速度的改善程度存在剂量依赖关系,对DPN有一定的保护作用。Objective： To investigate the influences of Tang Bi Kang on the Explore Tang Bi Kang sciatic nerve conduction velocity in STZ-induced diabetic peripheral neuropathy rat.Methods： Diabetes was induced by intraperitoneal injection of STZ,55mg/kg,The diabetic models were affirmed upon blood glucose ≥16.7mmol/L.And the diabetic rats were randomly divided into five groups： model group,methycobal treatment group,Tang Bi Kang different dose treatment grous.All the rats were sacrificed at week 12;HE staining of the right sciatic nerve were observed.The surface and in vivo sciatic nerve motor nerve conduction velocity （ MNCV）,sensory nerve conduction velocity （ SNCV） were measured.All statistical calculations were made using the SPSS16.0 statistical package.Results： After the treatment by Tang Bi Kang,the eighth week body weight,The sciatic nerve MNCV and SNCV increased greatly.Conclusions： Tang Bi Kang may increase the nerve conduction velocity of diabetic penipheral neuropathy to slow down the course of the diabetic penipheral neuropathy.

关 键 词：糖尿病周围神经变 糖痹康 坐骨神经 神经传导速度 

分 类 号：R285.5[医药卫生—中药学]