冬梅饮对早期糖尿病肾病肾组织基质金属蛋白降解酶-9作用的实验研究  

Effects of Dong Mei Decoction on Matrix Metalloproteinases-9 in Kidney Tissues of Early Diabetic Nephropathy

作　　者：周雪梅[1] 陈雪功[1] 傅裕[2] 王望九[1] 胡建鹏[1] 董昌武[1] 王建青[1] 程维克[1] 

机构地区：[1]安徽中医学院,安徽合肥230038 [2]安徽滁州市中西医结合医院,安徽滁州239000

出　　处：《中国中医基础医学杂志》2010年第3期212-213,216,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：安徽省教育厅自然科学研究资助项目(2006KJ095C)

摘　　要：目的:评价中药冬梅饮对早期糖尿病肾病(DN)大鼠肾组织基质金属蛋白酶-9(MMP-9)的影响,探讨其防治早期DN的作用机制。方法:用链尿佐菌素建立早期DN模型,观察冬梅饮对早期DN大鼠血糖、尿β2-MG、肾组织MMP-9的影响。结果:冬梅饮治疗组可升高模型大鼠肾组织MMP-9含量增加(P<0.05);降低24h尿β2-MG排泄率(P<0.05)。结论:冬梅饮对肾脏具有保护作用,可延缓DN的发展。Object： To evaluate the effects of DongMeiYin（DMY） on Matrix Metallo Proteinase-9 （MMP-9）in the diabetic rats,and to investigate the mechanism of DMY in preventing and treating early diabetic nephropathy（DN）.Methods： The rat early DN models were induced by injection streptozotocin （STZ）.The model rats were randomly divided into the model group,DMY group,Valsartan group.The course of treatment continued 8 weeks.Observing the changes of MMP-9 in the renal cortex.Results： Compared with the normal group,the level of MMP-9 decreased in the model group,the two treated groups could increased the level of MMP-9.especially the DMY group had the best effect.Conclusion： The protective effect of DMY on renal structure may be achieved by modulating the level of MMP-9.

关 键 词：糖尿病肾病 冬梅饮 基质金属蛋白酶-9 

分 类 号：R285.5[医药卫生—中药学]