冠状动脉介入检查治疗中水化联合碳酸氢钠预防造影剂肾病的研究  

作　　者：张玉莲[1] 孟颖辉[1] 

机构地区：[1]甘肃酒泉市人民医院,735000

出　　处：《中国社区医师（医学专业）》2010年第10期97-98,共2页

摘　　要：目的:探讨水化联合碳酸氢盐对造影剂肾病的预防作用。方法:选择159例接受冠状动脉造影检查(CAG)或冠状动脉造影+冠状动脉内支架植入术(CAG+PCI)的患者,随机分为水化联合碳酸氢盐研究组和常规治疗对照组,检测所有患者术前、术后第2天、第3天的血清肌酐水平。结果:治疗组78例发生3例(3.85%)造影剂肾病(CIN),对照组81例发生17例(21.0%)造影剂肾病(CIN),两组对比有统计学意义(P<0.05)。结论:水化联合碳酸氢盐组较常规治疗组可更显著地减少造影剂肾病的发生;且简单易行,安全有效。Objective To study the prevention of strengthened rehydration combine to bicarbonate therapy to patients with cardiovascular vessel disease from contrast - induced nephropathy（CIN） after the interventional therapy. Methods：Totally 159 patients were enrolled in this study. They were assigned into two groups： the treated group （n = 78 ） and the control group （ n = 81 ）. The treated group were received strengthened rehydration combine to bicarbonate therapy through offering oral administration and intravenous fluid infusion [ 1ml/（ kg · h） ]. The levels of serum creatinine were measured before and 2,3 days after percutaneous coronary intervention. Result：The incidence of CIN in the treated group was significantly lower than that in the control group （P 〈 0. 05 ）. Conclusions ： The postoperative strengthened rehydration combine to bicarbonate therapy can effectively prevent from contrastinduced nephropathy, and the methods are simple and effective.

关 键 词：冠状动脉介入检查治疗 水化碳酸氢钠 造影剂肾病 

分 类 号：R981.1[医药卫生—药品]