葛根抗腹泻药效组分实验研究  

Study on Active Components Alignment of Anti-diarrhea in Radix Puerariae

作　　者：黄伟强[1,2] 金哲雄[2] 张贵君[1] 刘娜[1,2] 文春先[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《现代生物医学进展》2010年第1期137-139,共3页Progress in Modern Biomedicine

摘　　要：目的:验证葛根抗腹泻的药效组分,为葛根的质量评价提供科学数据。方法:在经方葛根芩连汤的基础上分析葛根抗腹泻的药效组分,采用组合药理实验辅助验证药效组分。结果:抗腹泻相关实验中葛根水煎液中、高剂量组、葛根药效组分组、葛根芩连汤组与阴性对照组比较均有显著性差异(P<0.01)。结论:葛根素-大豆苷-大豆苷元-3'-羟基葛根素是葛根抗腹泻的药效组分。Objective：To verify the active components alignment of anti-diarrhea and provide scientific data for the quality evaluation on Radix Puerariae.Methods：To analyze the active components alignment of Radix Puerariae anti-diarrhea on the base of Gengen Qinlian Decoction.Combination pharmacological experiment was used to verify the active components alignment.Result：In the relevant experiments of anti-diarrhea,comparing with the control group,there was significant difference among the medium-dose group and the high-dose group of Radix Puerariae decoction,the active components alignment group of Radix Puerariae and Gengen Qinlian Decoction group（P0.01）.Conclusion：The puerarin,daidzin,daidzei and 3＇-hydroxy puerarin was the active components alignment of anti-diarrhea on Radix Puerariae.

关 键 词：葛根 抗腹泻 药效组分 质量评价 葛根芩连汤 

分 类 号：R285.6[医药卫生—中药学]