胰腺相关microRNAs研究进展  

The Progress of Pancreas related MicroRNAs Research

作　　者：刘律君[1] 卢光琇[1] 

机构地区：[1]中南大学生殖与干细胞工程研究所,湖南长沙410087

出　　处：《现代生物医学进展》2010年第1期173-177,共5页Progress in Modern Biomedicine

摘　　要：miRNAs是一类长约21-25nt的内源性的小非编码RNA(small noncoding RNA),它在基因的转录后调控中发挥着重要的作用。miRNAs可以通过与靶基因的mRNA的3'端UTR区完全或部分互补,进而降解该目的mRNA或阻止其翻译成相关蛋白,下调靶基因表达,以此参与个体发育、细胞分化、细胞增殖以及疾病发生过程中的基因表达调控。本文简要介绍miRNAs在胰腺发育、β细胞功能以及胰腺相关疾病中的研究进展。MiRNAs are small endogenous noncoding RNAs,about 21-25 nucleotides in length,which play important roles in posttranscriptional gene regulation.miRNAs can target mRNA with the 3 ＇-UTR perfectly or imperfectly complementary,thus the purpose of degradation of the mRNA or block its translation into proteins,downregulat gene expression.They play a crucial role in regulating development,cell differentiation,proliferation and diseases pathogenesis.In this review,we have discussed the functions of miRNAs in the pancreatic development,β-cell,diabetes and pancreatic cancer.

关 键 词：MICRORNAS 胰腺 发育 Β细胞 糖尿病 胰腺癌 

分 类 号：R322.57[医药卫生—人体解剖和组织胚胎学] R587.1[医药卫生—基础医学]