新的易损斑块血清标志物妊娠相关蛋白A研究进展  

Pregnancy-associated plasma protein-A:new serum marker of vulnerable plaque

作　　者：吴小凡[1] 陈韵岱[2] 王绿娅[3] 吕树铮[1] 

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029 [2]中国人民解放军总医院,北京100853 [3]北京市心肺血管疾病研究所,北京100029

出　　处：《现代生物医学进展》2010年第2期359-361,共3页Progress in Modern Biomedicine

基　　金：北京市科学技术委员会应用基础研究与战略高技术主题重大项目(D0906006000091;D0906006040191);北京市卫生局;北京市中医管理局青年科学研究资助项目(QN2007-29)资助课题

摘　　要：冠状动脉易损斑块破裂或腐蚀继发血栓形成是急性冠脉事件发生的病理基础,寻找易损斑块新血清标记物对于早期识别和干预高危患者至关重要。新近发现妊娠相关蛋白A(PAPP-A)参与动脉粥样硬化的发生发展,并且与斑块的不稳定性关系密切,是冠心病患者不良事件的预测因子。本综述主要介绍妊娠相关蛋白-A的生物学特性及其与心血管疾病以及易损斑块关系的研究进展,为临床诊断和治疗带来新的思路。Pathologic studies have demonstrated that disruption or erosion of vulnerable plaques and subsequent thromboses are the most important cause of acute coronary events. A biomarker able to detect vulnerable plaques could be very critical for identifying patients at high risk of developing myocardial infarction Recently,pregnancy-associated plasma protein-A（PAPP-A） has been shown to play a role in the development of atherosclerotic lesions and represent also a marker of atheromatous plaque instability and extent of cardiovascular disease. The present article focuses on the biologic characteristics of PAPP-A and the relationship between PAPP-A and cardiovascular disease as well as vulnerable plaque.

关 键 词：妊娠相关蛋白-A 易损斑块 急性冠脉综合症 

分 类 号：R541.4[医药卫生—心血管疾病]