12T强静磁场对小鼠前庭系统及学习记忆能力的影响  

Effects of 12 T strong static magnetic field on vestibular system and learning-memory capability of mice

作　　者：陈莹[1] 廖鲜艳[1] 洪晓彤[1] 翁新楚[1] 

机构地区：[1]上海大学生命科学学院,上海200444

出　　处：《现代生物医学进展》2010年第3期501-505,共5页Progress in Modern Biomedicine

摘　　要：目的:随着强静磁场的广泛应用,其生物安全性评估获得越来越多的关注。本文通过实验,评估强静磁场照射对小鼠前庭系统、学习记忆能力的影响及两者内在联系。方法:观察12T强静磁场照射2h条件下小鼠即时(2min内)效应和条件味觉厌恶反应情况,确定照射对小鼠前庭系统的影响;通过Y迷宫和Morris水迷宫实验,分析照射对小鼠学习记忆能力的影响。结果:研究发现照射后小鼠立即出现直立行为抑制、旋转平衡失调,以及持续10d的条件味觉厌恶反应,表明该照射对小鼠前庭系统造成了即时及持续影响。Y迷宫和Morris水迷宫分析结果表明照射后小鼠学习记忆能力未发生显著改变。结论:12T强静磁场2h照射对小鼠前庭系统存在显著影响和量效关系,照射可导致小鼠出现平衡失调,持续味觉厌恶的现象,但这种影响并非结构性或不可逆的,对小鼠学习记忆能力未造成影响。Objective：With the increasing applications of strong static magnetic field （SMF）, its bio-safety assessment is gaining more and more attention. Effects of strong SMF on vestibular system, learning-memory capability of mice and the intrinsic connection between them were investigated. Methods：Mice were exposed 2 h in 12 T strong SMF. After the exposure, instant effects （in 2 min） and conditioned taste aversion were observed to determine the effects of exposure on the vestibular system of mice; Y maze and Morris water maze test were conducted to analysis the SMF influence on the learning-memory capability of mice. Results：After the exposure on mice, rearing was suppressed and circling was induced immediately, and furthermore, a sustained 10 d conditioned taste aversion was appeared. These responses indicated this exposure induced both immediate and sustained impacts on the vestibular system of mice. Results of Y maze and Morris water maze showed the learning-memory capability of mice after exposure had no significant changes. Conclusions：2 h in 12 T strong SMF exposures has effects and dose-response relationship on the vestibular system of mice, and the exposure induced balance disorder and sustained taste aversion of mice, however, these effects are not structural or non-reversible, and they have no influence on the learning-memory capability of mice.

关 键 词：强静磁场 前庭系统 学习记忆 

分 类 号：Q64[生物学—生物物理学] Q95-3