miRNA与细胞分化的研究进展  

Advance on MicroRNA and Cell Differentiation

作　　者：吴家昌[1] 马琼[1] 邹贤飞 杨彤涛[1] 单乐群[1] 马保安[1] 

机构地区：[1]第四军医大学唐都医院骨肿瘤研究所 [2]广西75135部队卫生队

出　　处：《现代生物医学进展》2010年第3期567-571,584,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(30672143;30901784)

摘　　要：microRNA(miRNA)是一类长度为22nt的内源性的参与转录后调节的单链非编码小RNA。近年来的研究表明,miRNA在基因表达调控方面具有广泛和普遍的作用,参与了生物体发生发育、细胞增殖、细胞分化等生物学过程,尤其是其在干细胞的自我更新与多向分化的调节作用日益受到关注。我们查阅近年有关文献,介绍了miRNA的生成、作用机制、研究方法,论述及其对真核生物细胞分化的调控作用。microRNA （miRNA） is a group of endogenous non-coding single-stranded small RNA species 22 nucleotides in length, which take part in posttranscriptional regulation of gene expression.In recent years,studies have shown that miRNAs have been shown to be involved in regulating generally individual development,proliferation,differentiation and other biological processes.Especially its influence in self-renewal and differentiation of stem cell has attracted increasing attention.In this review,we briefly summarize the biology of miRNA,its molecular mechanism for gene regulation,and research approache,and discuss the role of miRNA regulation in cell differentiation during eucaryote development.

关 键 词：MICRORNA 细胞分化 基因调控 进展 

分 类 号：Q75[生物学—分子生物学] Q78