20(S)-原人参二醇药质体的制备及体外评价  

Preparation and study in vitro of 20(S)-protopanaxadiol pharmacosomes

作　　者：韩美华[1] 陈婧[2] 陈士林[1] 王向涛[1] 

机构地区：[1]中国医学科学院药用植物研究所,北京100193 [2]哈尔滨商业大学生命科学与环境科学研究中心药物研究所,黑龙江哈尔滨150076

出　　处：《中国中药杂志》2010年第7期842-846,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30600787)

摘　　要：目的:研制20(S)-原人参二醇(Ppd)药质体和Brij78修饰的Ppd药质体并对其进行体外评价。方法:采用薄膜超声法制备Ppd药质体和Brij78修饰的Ppd药质体,用超速离心法测包封率,用动态光散射(DLS)考察粒径分布,以粒径和包封率为指标,分别考察温度、乙醇、酸碱和人工胃肠液等对药质体的影响。结果:薄膜超声法制备的Ppd药质体的包封率为(80.84±0.53)%,粒径100.1 nm;Brij78修饰的Ppd药质体的包封率为(72.76±0.63)%,粒径为117.3 nm。结论:该药质体制备工艺简单可行,制剂学性质较稳定。20 （S）-Protopanaxadiol （Ppd） pharmacosome was successfully prepared by thin film-dispersion and its stability in vitro was studied. The particle size of pharmacosome was evaluated by dynamic scattering （DLS） and the encapsulation efficiency was determined using centrifugal ultra-filtration. The encapsulation efficiency of Ppd pharmacosome was （80.84±0.53） % with the diameter of 100.1 nm; while the encapsulation efficiency of Ppd pharmacosome of Brij 78 added was （72.76±0.63）% with the diameter of 117.3 nm. In addition, the effect of some factors on the encapsulation efficiency and the particles size, such as temperature, alcohol, pH and artificial gastrointestinal fluids, was investigated respectively. The selected formulation and technology are simple and practical to prepare Ppd pharmacosome and preparation properties were more stable.

关 键 词：20(S)-原人参二醇药质体 包封率 超速离心法 粒度分布 稳定性 

分 类 号：R944[医药卫生—药剂学] R96[医药卫生—药学]