芍药苷和芍药内酯苷的微生物转化  

Microbiological transformation of paeoniflorin and albiflorin

作　　者：刘鑫鑫[1] 马骁驰[2] 霍长虹[1] 于树宏[1] 王巧[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017 [2]北京大学医学部药学院,北京100083

出　　处：《中国中药杂志》2010年第7期872-875,共4页China Journal of Chinese Materia Medica

基　　金：河北省自然科学基金项目(08B031);河北省教育厅项目(2006133)

摘　　要：目的:研究芍药苷和芍药内酯苷的微生物转化。方法:从18种真菌中筛选出分别对芍药苷和芍药内酯苷转化能力强的菌株进行转化,采用色谱和波谱技术分离鉴定转化产物。结果:对芍药苷和芍药内酯苷转化能力较强的菌株分别是短刺小克银汉霉AS 3.970和总状共头霉AS 3.264。短刺小克银汉霉AS 3.970可将芍药苷转化为芍药内酯苷,总状共头霉AS 3.264可将芍药内酯苷转化为芍药苷。结论:特定条件下,芍药苷和芍药内酯苷可以相互转化。Objective： To investigate the microbiological transformation of paeoniflorin and albiflorin. Method： The bacteria strains able to transform paeoniflorin and albiflorin were screened from 18 strains of microorganisms. The products were isolated by chromatography method and their structures were elucidated by spectral technology. Result： Cunninghamella blakesleana （AS 3.970） and Syncephalastrum racemosum （AS 3.264） were found to convert paeoniflorin and albiflorin efficiently,respectively. C. blakesleana could convert paeoniflorin to produce albiflorin,while S. racemosum could convert albiflorin to produce paeoniflorin. Conclusion： Paeoniflorin and albiflorin could be converted each other in definited condition.

关 键 词：芍药苷 芍药内酯苷 微生物转化 短刺小克银汉霉 总状共头霉 

分 类 号：R284.1[医药卫生—中药学]