微通道内红细胞流动与变形的可视化研究  

FLOW VISUALIZATION OF ERYTHROCYTES MOTION AND DEFORMATION IN MICROCHANNEL

作　　者：郭放[1] 向浩[1] 陈斌[1] 

机构地区：[1]西安交通大学动力工程多相流国家重点实验室,陕西西安710049

出　　处：《工程热物理学报》2010年第4期621-624,共4页Journal of Engineering Thermophysics

基　　金：国家自然科学基金项目(No.50976087);教育部新世纪优秀人才计划项目(No.NCET-07-0661);教育部科学技术研究重点项目(No.107101)

摘　　要：微循环条件下,红细胞的尺寸与血管相近,血液不能视为均质流体,其流动表现出较强的颗粒性,红细胞流变特性对血液流动有较大影响。本文使用高倍显微镜对微流控芯片矩形截面微通道内红细胞的流动和变形特性进行可视化观察研究,并使用高速CCD相机拍摄和捕捉了红细胞在微通道内的流动和变形过程。通过观察不同浓度、粘度和速度下红细胞的聚集性、变形性以及常见的运动形态,发现红细胞在低粘度、低速流动条件下表现为两面凹圆盘形,沿流动方向运动过程总是伴随着翻转与旋转;在高粘度、高速运动条件下,红细胞表现为扁平椭圆形、呈坦克履带式(TTM)前进。The dimension of erythrocyte is close to capillary diameter and in microcirculation blood should be treated as a two-phase flow system,i.e.,erythrocytes suspended in plasma.The rheological property of erythrocytes will significantly influence the hemodynamics.In our experiment,the motion and deformation of erythrocytes in a microfluidic chip with rectangular cross-section microchannel was captured by optical microscope and high speed CCD camera.The aggregation,deformation and common movement forms of erythrocytes were observed under different viscosity,hematocrit and velocity.It was found that erythrocytes behaved a regular biconcave disc shape at low velocity and low-to-medium viscosity,and always rolled and rotated themselves in their movement.At high velocity and medium viscosity,RBCs elongated obviously along the flow direction and presented a flat oval shape together with a tank-treading motion（TTM）.

关 键 词：红细胞 微通道 微流控芯片 可视化 

分 类 号：R331.14[医药卫生—人体生理学]