大鼠伏核中胆囊收缩素对学习记忆的影响机制  

EFFECTS OF CCK IN NUCLEUS ACCUMBENS OF THE RATS ON LEARNING AND MEMORY

作　　者：倪宏[1] 徐珞[1] 唐明[1] 

机构地区：[1]青岛医学院生理学教研室

出　　处：《青岛医学院学报》1998年第4期243-245,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省卫生厅科研基金

摘　　要：目的研究大鼠伏核中胆囊收缩素（ＣＣＫ）调节学习记忆的受体机制。②方法采用行为和脑核团内微量注射相结合的方法，利用三等分辐射式迷宫模型观察大鼠伏核中胆囊收缩素对分辨学习（ＤＬ）和条件性回避反应（ＣＡＲ）的影响。③结果双侧伏核中后区注射ＣＣＫ－Ａ受体阻断剂Ｌ－３６４，７１８对ＤＬ和ＣＡＲ有明显的抑制效应（ｔ＝６．５０，８．５５，Ｐ＜０．０１），而ＣＣＫ－Ｂ受体阻断剂Ｌ－３６５，２６０对ＤＬ和ＣＡＲ无影响（ｔ＝２．１４，２．１４，Ｐ＞０．０５）。④结论伏核中后区内ＣＣＫ－Ａ受体参与对ＤＬ和ＣＡＲ的调节，提示伏核中后区内源性ＣＣＫ对学习记忆过程具有促进作用，并且是通过ＣＣＫ－Ａ受体实现的。Objective To determine the receptor subtype mediating the modulatory actions of CCK in the medial posterior nucleus accumbens of the rats on learning and memory. Methods CCK was injected into medial posterior nucleus accumbens of rats. The effects of CCK on discrimination learning(DL) and conditional avoidance response(CAR) were studied in the three-panel runway test in rats. Results Injection of CCK-A receptor antagonist L-364, 718 into the medial posterior nucleus accumbens of rats showed significantly inhibitory effect on DL and CAR(t=6.50,8.55,P<0 .01), while CCKB reptor antagonist L365, 260 showed no effect on DL and CAR(t=2.14,2.14,P>0.05). Conclusion Autologous CCK in medial posterior nucleus accumbens participated in the regulation of DL and CAR through CCKB receptor. CCKB receptor exerted no effect.

关 键 词：伏核 胆囊收缩素 学习 记忆 受体 大鼠 CCK 

分 类 号：R338.64[医药卫生—人体生理学]