山东省1993～1996年临床脊髓灰质炎病例分析  

Analysis of Clincal Poliomyelitis in Shandong Province from 1993-1996

作　　者：雷杰[1] 李黎[1] 徐爱强[1] 刘桂芳[1] 刘萍[1] 王同展[1] 姜萍[1] 周晓琳[1] 王海岩[1] 

机构地区：[1]山东省卫生防疫站,济南250014

出　　处：《中华流行病学杂志》1998年第6期327-329,共3页Chinese Journal of Epidemiology

摘　　要：1993～ 1996年间山东省有 71例临床诊断脊髓灰质炎病例 ,50例考虑与脊灰疫苗有关。按疫苗投放量统计相关病例发生率为 1/12 5万 ,首次服苗发生率为 1/2 1.88万 ,第二次服苗为 1/10 1.0 7万。用有病毒学支持的 31例分析 ,首次服苗发生率为 1/43.80万 ,第二次服苗为 1/164.2 5万。接触病例发生率为 1/10 4 4万 ,高于有关报道 ,其原因仍需进一步探讨。其它 2 1例仅临床上诊断为脊灰 ,但无病毒学支持。如何正确对脊灰临床病例分类是一个值得探讨的问题。Wild poliovirus has not been isolated in Shandong province since Apr.1991. However,71 clinically polio cases were diagnosed by an expert group, including 50 potential Vaccine Associated Paralytic Poliomyelitis (VAPP) including 31 having the sabin strain in the stools, from 1993 to 1996. The overall frequency of VAPP was one case per 1.25 million doses distributed. The relative frequencies of first dose in the OPV series was one case per 218 800 doses vs one case per 1.01 million for second dose. Based on data from the 31 cases,we estimated that the rates had been one case per 438 000 first dose and one case per 6.42 million second dose and one case per 10.44 million among the contacts of the cases. This results seemed to be higher than from other reports. Clinically confirmed poliomyelitis cases in Shandong were diagnosed by the experts group. The classification of clinical polio cases is important in the polio eradication program.

关 键 词：脊髓灰质炎 疫苗 发生率 分类 山东 

分 类 号：R512.4[医药卫生—内科学]