预防放射性口腔黏膜反应方法的探讨  

Investigation on the methods to prevent radiotherapy-induced oral mucositis

作　　者：杨秀云[1] 晏晓波[2] 

机构地区：[1]山东省立医院内科,济南250021 [2]山东省胸科医院护理部

出　　处：《中国实用护理杂志》2010年第4期13-15,共3页Chinese Journal of Practical Nursing

基　　金：山东省科技攻关项目（2008GG30002045）

摘　　要：目的探讨预防头颈部肿瘤患者放疗所致口腔黏膜反应的有效方法。方法将92例头颈部肿瘤放疗患者随机分为A组31例，B组31例，C组30例。A组每次放疗前、后1h给鱼腥草注射液20ml＋丹参注射液20ml＋蒸馏水30ml雾化吸入，20min／次，至放疗结束。B组给予康复新注射液2ml＋维生素B12注射液0．5mg＋生理盐水50ml雾化吸入，方法同A组。C组采用中草药养阴清肺汤方剂水煎取汁500ml，分别在放疗前、后1h各服一半，至放疗结束。比较3组口腔黏膜反应的发生情况。结果A组患者Ⅱ级、Ⅲ级口腔黏膜反应发生率及严重程度均明显低于B、C组。结论鱼腥草、丹参注射液合剂雾化吸入预防放射性口腔黏膜反应的临床效果显著。Objective To investigate effective methods for preventing radiotherapy-induced oral mucositis among patients with cephalocervical malignant tumors. Methods 92 patients with cephalocervical malignant tumors treated with radiotherapy were randomly divided into group A （31 cases）,group B （31 cases） and group C （30 cases）. Mixture of 20 ml heartleaf houttuynia herb injection,20 ml salvia injection and 30 ml distilled water were given to patients in group A by means of nebulization inhalation one hour before and after every radiotherapy treatment, the inhalation lasted 20 minutes each time up to the end of radiotherapy. Mixture of 2 ml Kang-fu-xin injection,0.5 mg vitamin B~： injection and 50 ml normal saline were given to patients in group B by the same means as group A. Yangyin Qingfei decoction were given to patients in group C by means of selecting its 500 ml juice for oral use. Half of the 500 ml decoction were separately given 1 hour before and after each radiotherapy treatment up to the end of radiotherapy. Results The incidence rates of oral mucositis were obviously lower among patients in group A than in group B and C. Conclusions Nebulization inhalation of mixture of hearfleaf houttuynia herb and salvia injections has significant clinical effects on oral mucositis after radiotherapy.

关 键 词：鱼腥草 丹参注射液 放射治疗 口腔黏膜反应 

分 类 号：R473.73[医药卫生—护理学]