肠道正常菌丛对轮状病毒感染拮抗作用的病理观察  

Pathology of the Resistances of Normal Intestinal Floras on Rotavirus Infection

作　　者：张永容[1,2,3] 马晓彤 黄澜[1,2,3] 张 蒋观成 魏强[1,2,3] 王玉琢 朱华[1,2,3] 张原 

机构地区：[1]中国医学科学院实验动物研究所 [2]中国协和医科大学实验动物学部 [3]中国医学科学院医学信息研究所

出　　处：《实验动物科学与管理》1998年第4期17-20,共4页Laboratory Animal Science & Administration

基　　金：中国医学科学院青年基金

摘　　要：新生无菌ＢＡＢＣ／Ｌ小鼠投以６种肠道正常细菌，于第５日龄感染鼠轮状病毒，每日处死动物２只，直到第５天，实验２组动物（肠道正常菌丛＋，轮状病毒＋）较实验１组动物（肠道菌丛－，轮状病毒＋）腹泻出现晚、恢复快，肠绒毛上皮细胞水样变性轻、范围小、炎性细胞浸润明显。Newborn germ free BALB/c mice were innoculated 6 species of normal intestinal floras and infected rotavirus at the fifth day. Two mice were killed each day untill the fifth day. Animals of the second experiment group (normal intestinal floras+,rotavirus+)appeared dirrhea later and recovered sooner than the animals of the first experiment group (normal intestinal floras-, rotavirus+). As well as the slight water degeneration ,there were also small cope of pathological changes and significant inflamation in the vili of intestine of the animals in the second experiment group. The results indicated that normal intestinal floras bear the resistant role on the infection of rotavirus.

关 键 词：无菌小鼠 肠道正常菌丛 轮状病毒 拮抗作用 

分 类 号：R333.3[医药卫生—人体生理学] R363.2[医药卫生—基础医学]