蝮蛇抗栓酶对冻伤家兔血凝系统某些指标的影响  

EFFECTS OF AHYLYSANTINFARCTASE ON SOME PARAMETERS OF BLOOD COAGULATION SYSTEM IN FROSTBITTEN RABBITS

作　　者：颜培华[1,2] 李凤芝[1,2] 田嘉荣 吴怀春[1,2] 李森 邸文学[1,2] 

机构地区：[1]军事医学科学院卫生学环境医学研究所 [2]解放军224医院

出　　处：《中国应用生理学杂志》1998年第4期320-322,共3页Chinese Journal of Applied Physiology

摘　　要：本研究观察了家兔双后足重度冻伤后用蝮蛇抗栓酶（０．２５Ｕ／ｋｇ体重加入２０ｍｌ／ｋｇ体重生理盐水中，耳缘静脉点滴）进行治疗后其血凝系统某些指标的改变。结果表明，重度冻伤后家兔的出血时间及凝血时间明显缩短，血小板功能呈不同程度的改变，血浆纤维蛋白原含量增加，血液处于高凝状态；用蝮蛇抗栓酶治疗后，上述各项指标均有不同程度的改善，结果提示，蝮蛇抗栓酶可明显缓解冻伤所致的血凝增强的病变过程。The effects of ahylysantinfarctase on some parameters of the blood coagulation system in rabbits fo llowing cold injury of both hind feet were investigated. The ahylysantinfarctase (0. 25U/ kg) was injected through the vein of ear, The results showed that in frostbitten rabbits, the bleeding time and clotting time were shortened; the plasma fibrinogen content was enhanced. But in the treatment group, the bleeding time and clotting time were significantly longer; the rate of platelet aggregation and rate of platelet adhesion were markedly less; and the plasma fibrinogen content was lower than that of the frostbite control group. It is suggested that the treatment effect of ahylysantinfarctase on frostbite was due to the reduction of the blood coagulability.

关 键 词：冻伤 血液凝固 蝮蛇抗栓酶 

分 类 号：R645[医药卫生—外科学]