性别差异对大鼠中央杏仁核多巴胺释放的影响  

THE EFFEXT OF SEX DIFFERENCES ON DOPAMINE OVERFLOW FROM CENTRAL AMYGDALOID NUCLEUS IN RATS

作　　者：谢俊霞[1] 唐明[1] 

机构地区：[1]青岛医学院生理教研室

出　　处：《中国应用生理学杂志》1998年第4期364-367,共4页Chinese Journal of Applied Physiology

摘　　要：用快速周期伏安法，测定了电刺激对不同性别大鼠的多巴胺（ＤＡ）能细胞体区－腹侧背盖区（ＶＴＡ）诱发的中央杏仁核（ＣｅＡ）ＤＡ释放的影响，并初步分析了释放量与性别之间的关系。结果表明：雌、雄和去卵巢（ＯＶＸ）雌鼠ＣｅＡ的ＤＡ释放量取决于电刺激的参数，且释放动力学慢于我们以前在纹状体观察到的结果。相同刺激参数诱发的雌鼠ＤＡ释放量明显高于雄鼠和ＯＶＸ雌鼠，表明电刺激ＶＴＡ诱发的ＣｅＡ的ＤＡ释放不仅取决于刺激参数。Using fast cyclic voltammetry(FCV),we studied DA overflow from the central amygdaloid nucleus (CeA) evoked by electrical stimulation of ventral tegmental area(VTA) in male,female and ovariectomized(OVX) female rats.The relationship between DA overflow value and sex difference was briefly analysed. The results showed that DA overflow was significantly dependent upon the stimulating parameters,and the kinetics of DA overflow from CeA was slower than thos from the striatum in our previous study.The amount of DA overflow evoked by the same stimulating parameters in female rats was significantly higher than those in male and OVX female rats ( P <0.05￣0.001).The data suggest that DA overflow from CeA evoked by electric stimulation of VTA depends not only on stimulating parameters,but also on sex hormone.

关 键 词：中央杏仁核 多巴胺 性别差异 电刺激 

分 类 号：R338.8[医药卫生—人体生理学]