精氨酸对烧伤大鼠免疫功能的影响  

Effects of Arginine on Immune Function in Burned Rats

作　　者：王先远[1] 金宏[1] 许志勤[1] 王宗印[1] 高兰兴[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所

出　　处：《氨基酸和生物资源》1998年第4期1-5,共5页Amino Acids & Biotic Resources

摘　　要：旨在观察烧伤后补充Ａｒｇ对大鼠血清免疫球蛋白、ＴＮＦ、吞噬细胞功能的影响。用Ｗｉｓｔａｒ大鼠，１８０±１０ｇ，Ⅲ°烧伤后１，３，７，１０天取血测定免疫球蛋白Ａ、Ｇ、Ｍ，及ＴＮＦ水平，并于烧伤后第３天取腹腔吞噬细胞观察其功能，计算其吞噬指数、吞噬率。结果烧伤大鼠血清ＩｇＡ、ＩｇＧ、ＩｇＭ水平降低，ＴＮＦ水平明显升高，吞噬细胞功能下降；饲喂补充Ａｒｇ的饲料后，血清免疫球蛋白水平、吞噬细胞功能均有所改善，ＴＮＦ水平降低。说明烧伤后补充Ａｒｇ可以改善机体免疫状态。To study the effects of arginine on the phagocytosis, the level of serum TNF and immunoglobin A,G, and M, from the burn rat, the contents of IgA, IgG, IgM and TNF fromwistar rats on the day 1,3,7,10 of postburn were determined, while the phagocytic index and phagocytic rate were determinde on the day 3 of postburm. It was found that the level of serum immunoglobins and phagocytosis decreased, while TNF level increased. The phagotytosis and the level of serum immunoglobins from the rats received the diets supplied with arginine was reised while the content of TNF decreased, Supplementation of arginine could improve immune status of the burned rats.

关 键 词：精氨酸 烧伤 免疫球蛋白 肿瘤坏死因子 

分 类 号：R392[医药卫生—免疫学] R644[医药卫生—基础医学]