比索洛尔改善不稳定型心绞痛窦性心率震荡  

Effect of bisoprolol on heart rate turbulence in patients with unstable angina pectoris

作　　者：陈英杰[1] 陈运立[1] 吴贤仁[1] 黄林喜[1] 

机构地区：[1]汕头大学医学院第一附属医院急诊科,广东省汕头515041

出　　处：《中国基层医药》2010年第4期433-434,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察比索洛尔对不稳定型心绞痛（UAP）恶性室性心律失常的发生以及窦性心率震荡（HRT）的影响，探讨13受体阻断剂预防冠心病心源性猝死的机制。方法选择合并有室性期前收缩的UAP患者40例，所有患者在常规治疗的基础上服用比索洛尔5mg／d，在患者开始服用比索洛尔前24h和连续服用7d后分别行动态心电图检查，计算窦性心率震荡的初始值（TO）、斜率（TS）以及发生恶性室性心律失常的患者数。结果连续服用比索洛尔7d后与服药前对比，UAP患者恶性室性心律失常发生率减少14．2％，TO也明显降低，而髑较前增加，HRT有明显改善。结论HRT降低可作为预测UPA恶性室性心律失常发生的指标之一；比索洛尔通过改善HRT减少恶性室性心律失常的发生。Objective To observe the effect of bisoprolol on malignant ventrieular arrhythmia （MVA） and heart rate turbulence （HRT） in ambulatory electrocardiogram monitoring for twenty-four hours in patients with unsta- ble angina pectoris （UAP）. Methods 40 UAP patients with premature ventrieular beats were observed. All patients were examined with ambulatory electrocardiogram monitoring for twenty-four hours before and after bisoprolol （5rag, Qd） was administered for 7 days. The number of patients with MVA^turbulence onset （TO） and turbulence slope （TS） were analyzed. Results After bisoprolol was administered for 7 days in patients with UAP,the number of pa- tients with .MVA decreased by 14.2%. TO decreased and TS increased, and HRT was improved. Conclusions HRT had clinical prognostic value for malignant ventricular arrhythmia and sudden death in patients with UPA. Bisoprolol can improve HRT and reduce the incidence of MVA,

关 键 词：比索洛尔 心绞痛 不稳定型 心率 心律失常 

分 类 号：R541[医药卫生—心血管疾病]