布桂嗪合用维拉帕米的镇痛作用研究  

Study on analgesic effects of combination of fortanodyn and verapamil

作　　者：李兵[1] 张雷[1] 郑芙林[1] 

机构地区：[1]安徽理工大学医学院药理教研室,安徽省淮南232001

出　　处：《中国基层医药》2010年第4期441-442,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：安徽理工大学青年科学研究基金项目（DC,647）

摘　　要：目的研究钙拈抗药维拉帕米（Ver）对布桂嗪（AP237）镇痛作用的影响。方法应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察Ver合用AP237对疼痛的抑制作用。结果低剂量Ver合用AP237（40mg／kg，80mg／kg）可明显提高小鼠诱发疼痛反应的痛阈值，推迟小鼠疼痛出现的时间（与单用AP237比较，P〈0．05，与对照组比较，P〈0．01）；低剂量Ver合用AF237（20mg／kg，40mg／kg）对小鼠扭体反应次数有明显的抑制作用（与单用AP237比较，P〈0．05；与单用AP237比较，P〈0．01）。结论Ver可增强AP237的镇痛作用。Objective To study the analgesic effects of combination of fortanodyn and verapamil. Methods Used the model of the acetic acid induction writhing in mice and the method of hot-plate in mlce,then observe the action of the mice after treatment with combination of fortanodyn and verapamil. Results Low dose Verapamil com- bined AP237 （40 mg/kg,80 mg/kg）could enhance the threshold of pain of the mouse ache response obviously, and postponed the time which the mouse ache appeared （ comparing using simply AP237 P 〈 0.05 with controlled group P 〈 0.01 ） ;Low dose Vcrapamil combined AP237 （20 mg/kg,40 mg/kg） had the obvious inhibitory action in the body turning times of the mouse. Conclusion Verapamil can strengthen the analgesia function of AP237.

关 键 词：镇痛药 维拉帕米 疼痛测定 

分 类 号：R9[医药卫生—药学]