贵州彝族乙型肝炎病毒感染与IL-10 592位点及ESR1 T29C位点多态性相关性研究  

Study on association of IL-10 592 and ESR1 T29C gene polymorphism with susceptibility to hepatitis B viras infection in Yi minority from Guizhou

作　　者：单可人[1] 王婵娟[1] 龙丽[1] 何燕[1] 张婷[1] 李毅[1] 谭奎[1] 涂茜[1] 任锡麟[1] 官志忠[1] 

机构地区：[1]贵阳医学院分子生物学重点实验室,贵阳550004

出　　处：《中国实用内科杂志》2010年第4期334-336,共3页Chinese Journal of Practical Internal Medicine

基　　金：贵州省科技厅科技计划课题资助黔科合SY字[2008]3053;贵州省省长基金黔科教办[2005]14号;贵州省科技厅科研基金项目资助黔科合J字[2005]2016号;贵州省科技厅科研基金项目资助黔科合J字[2007]2032

摘　　要：目的研究贵州世居少数民族---彝族人群白介素-10(IL-10)592位点和雌激素受体(ESR1)T29C位点多态性与乙型肝炎病毒(HBV)易感性的相关性。方法对选择的彝族人群采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法分析IL-10592位点和ESR1 T29C位点多态性。结果IL-10592位点彝族感染组与非感染组的分布差异有统计学意义(P<0.05),而ESR1T29C位点多态性在彝族感染组与非感染组中的分布无统计学意义(P>0.05)。结论IL-10592位点多态性与彝族HBV感染情况可能存在相关性,IL-10592位点多态性可能是乙型肝炎易感性的因素之一。Objective To investigate the association of IL-10 592 and ESR1 T29 C gene polymorphism with the susceptibility to hepatitis B virus in Yi minority of Guizhou. Methods Allelic frequencies of IL-10 592 and ESR1 T29 C were identified by PCR-RFLP. Results IL-10 592 polymorphism was associated with the suseepti- bility to HBV in Yi minority. There wasno association between ESR1 T29 C gene polymorphism and the suscepti- bility to hepatitis B virus in Yi minority. Conclusion IL-10 592 polymorphisms influence the susceptibility to HBV infection in Yi minority of Guizhou. The study suggests that IL-10 592 polymorphism may be a dangerous fac- tor of HBV infection.

关 键 词：贵州彝族 白介素-10基因 雌激素受体基因 

分 类 号：R5[医药卫生—内科学]