痰热清注射液治疗创伤性急性肺损伤的疗效观察  

Clinical Observation of Tan-re-qing Injection on Acute Lung Injury Patients

作　　者：阳世雄[1,2] 赵永亮[1,2] 曾建业[1,2] 韦涌初[1,2] 黄思光[1,2] 卢苇[1,2] 

机构地区：[1]广西医科大学第三附属医院 [2]广西南宁市第二人民医院心胸外科,南宁市530031

出　　处：《广西医学》2010年第2期144-147,共4页Guangxi Medical Journal

基　　金：广西医疗卫生科学研究基金(桂卫科Z200844)

摘　　要：目的探讨痰热清在创伤性急性肺损伤的肺保护作用。方法59例创伤性急性肺损伤患者随机数字表法分为痰热清组29例和常规治疗组30例,两组均给予治疗原发病及循环呼吸支持、抗感染、手术等综合治疗,痰热清组在上述治疗的基础上加用痰热清注射液20 ml/d,疗程7 d。观察两组治疗前后动脉血气、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、SIRS评分的变化;比较两组ARDS的发生率和病死率的差异。结果治疗后痰热清组较常规治疗组的动脉血气、SIRS评分明显改善(P<0.05),血清IL-6、IL-8、TNF-α水平明显降低(P<0.05),且低于常规治疗组;ARDS的发生率和病死率两组无统计学意义(P>0.05)。结论痰热清能降低急性肺损伤患者的血清TNF-α、IL-6、IL-8炎性因子的水平,缓解炎性反应综合征的进展,能改善通气,缓解呼吸窘迫。Objective To explore the protective effect of Tan-re-qing injection on acute lung injury（ALI）patients.Methods 59 of ALI patients were enrolled in our study and divided into two groups by random number table.One group including 30 patients was served as general treatment group,and the other including 29 patients was administrated with Tan-re-qing injection besides general treatment.Changes of arterial blood gas were observed,and IL-6,IL-8 and TNF-α were compared between the two groups 7 days after treatment.The incidence of ARDS and mortality were also compared each other.Results In Tan-re-qing group,arterial blood gas and SIRS score were better than those in general group（P〈0.05）;and the serum levels of IL-6,IL-8,TNF-α in Tan-re-qing group were lower than those in general group（P〈0.05）;Mortality and incidence of ARDS had no difference in statistics between general group and Tan-re-qing treatment group（P〉0.05）.Conclusion Tan-re-qing injection could reduce the serum levels of inflammatory factors as TNF-α,IL-6 and IL-8.It also slows down the progress of SIRS and improves gas exchange in ALI,relieves degree of respiratory distress.

关 键 词：急性肺损伤 呼吸窘迫综合征 痰热清 

分 类 号：R563.8[医药卫生—呼吸系统]