新生儿先天性心脏病危险因素分析  

Analysis of the risk factors of congenital heart diseases

作　　者：郭佳林[1] 洪向丽[1] 姚明珠[1] 

机构地区：[1]同济大学附属第一妇婴保健院新生儿科,上海200040

出　　处：《中国新生儿科杂志》2010年第2期76-79,共4页Chinese Journal of Neonatology

摘　　要：目的探讨新生儿先天性心脏病(简称先心病)的类型及其可能的危险因素。方法选择2004—2008年在本院出生的165例先心病患儿和同期出生的202例健康儿进行病例对照研究,了解先心病的类型,用单因素卡方检验和多元回归分析其可能的危险因素。结果病例组中室间隔缺损87例,占52.7%,房间隔缺损17例,占10.3%,各类复杂先心病共占29.7%,以完全性大血管转位最多见,其次为法洛四联症。孕早期感冒服药、糖尿病合并妊娠或妊娠期糖尿病、高龄产妇(>35岁)、曾接触杀虫剂或类似药、母亲孕前或孕早期饮酒史、主被动吸烟史、妊娠期高血压疾病、孕早期接触室内装修物及油漆、先兆流产并服药及病毒感染均是先心病发生的相关危险因素(P<0.05)。结论应加强孕期健康教育,提高产前产后诊断水平,以早期防治先心病。Objective To investigate the different types of neonatal congenital heart diseases （CHD） and their correlative risk factors for the purpose of establishing early prophylaxis and treatment. Methods A case-control study was performed between 165 cases with CHD and 202 normal newborns. All the subjects were the in-patient newborns in our pediatric ward from Jan 2004 to Dec 2008. Results Total 165 infants with congenital heart diseases were detected. The most common deformations were ventricular septal defect,accounting for 52.7% （87 cases）,followed by 17 atrial septal defect cases （10.3%）. About 29.7% of all the cases were classified into complex congenital heart disease group,such as complete transposition of great vessels and tetralogy of fallot. Most of them were found to be complicated with other organ malformations. The risk factors linked to CHD are inappropriate drug use for common cold or threatening abortion,gestational hypertension disease,elder pregnant women,gestational diabet...更多es mellitus,contact history of poisonous chemistry,history of drinking or smoking,and various virus infection. Conclusion In order to decrease the occurence of CHD,prenatal health education should be strengthened to improve the awareness of protection in child-bearing women and pregnant women.The exposure to environmental pollution should be reduced,and at the same time,the prenatal or postpartum diagnostic technique should be improved for the benefit of early prevention and treatment.

关 键 词：心脏病 先天性 危险因素 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]