hs-CRP和D-D与冠心病关系的研究  

THE RELATIONSHIP BETWEEN HIGH SENSITIVE C-REACTIVEPROTEIN,D-DIMER AND CORONARY HEART DISEASE

作　　者：高建钢[1] 宿瑞俊[1] 刘云彪[1] 张丽英[1] 

机构地区：[1]内蒙古医学院附属医院临床检验中心,内蒙古呼和浩特010050

出　　处：《内蒙古医学院学报》2010年第1期6-8,共3页Acta Academiae Medicinae Neimongol

基　　金：内蒙古医学院青年科研基金(NY2006QN008)

摘　　要：目的:测定超敏-C反应蛋白(hs-CRP)、D-二聚体(D-D)在冠心病外周血中含量,探讨两者在冠心病诊治中的价值。方法:随机选择住院确诊冠心病140例为观察组其中急性心肌梗死组(AMI)为50例、不稳定型心绞痛组(UAP)为40例、稳定型心绞痛组(SAP)为50例;体检健康者100例为对照组;用免疫比浊法测定Hs-CRP、D-D。结果:急性心肌梗死(AMI),不稳定型心绞痛(UAP)病人hs-CRP、D-D含量明显高于稳定型心绞痛病人(SAP)和对照组(P<0.01)。具有统计学意义,差异显著。hs-CRP的测定值,稳定型心绞痛病人(SAP)和对照组相比(P<0.05),具有统计学意义,而D-D则无统计学意义(P>0.05)。结论:hs-CRP、D-D能较好地反映冠心病的病情变化,有助于早期诊断、治疗分型、疗效判定。Objective： To observe the content changes of high sensitive C - reative protein （ hs - CRP） and D -Dimer （D -D） in peripheral blood of patients with coronary heart disease, and discuse the value of clinical application in coronary heart disease. Methods ：140 patients with coronary heart disease were divided into AMI group （n =50） ,UAP group （n =40） and SAP group （n =50）. 100 health examination volunteer served as control group, hs - CRP and D - D were measured by turbidi- metric immunoassay. Results：The content of hs - CRP and D - D in AMI group and UAP group are higher than control group and SAP group （P 〈0. 01 ） and have significant difference. The level of hs - CRP have significant difference between SAP group and control group （P 〈 0. 05 ）, and there were no significant difference between SAP group and control group （ P 〉 0. 05 ）. Conclusion： hs - CRP and D - D can better reflect the severe degree of coronary heart disease, and have very important clinical ap- plication in early diagnosis.

关 键 词：HS-CRP D-D 冠心病 不稳定型心绞痛 稳定型心绞痛 

分 类 号：R965[医药卫生—药理学]