趋化因子IP-10在病理性瘢痕组织中的表达及意义  

Expression of IP-10 and Its Significance in Pathological Scar

作　　者：于学伟[1] 郭澍[1] 肖汀[2] 王晨超[1] 张欣[1] 

机构地区：[1]中国医科大学附属第一医院整形外科 [2]中国医科大学附属第一医院皮肤科,沈阳110001

出　　处：《中国医科大学学报》2010年第3期165-167,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(30400389);教育部高等学校博士学科点专项科研基金资助项目(20060159014);辽宁省创新团队基金资助项目(2008T192)

摘　　要：目的研究趋化因子γ干扰素诱导蛋白10(IP-10)在病理性瘢痕中的表达,探讨其在病理性瘢痕发病机制中的作用。方法应用免疫组化技术检测趋化因子IP-10在28例瘢痕疙瘩(K组)、34例增生性瘢痕(HS组)及20例正常皮肤(N组)中的表达,并进行统计学分析。结果IP-10在K组及HS组中均呈高表达,与N组比较差异均具有统计学意义(P<0.01),但K组与HS组之间差异无统计学意义(P>0.05)。结论IP-10可能通过趋化T淋巴细胞定向迁移,引发一系列免疫炎性反应,从而促进病理性瘢痕的形成。Objective To explore the expression of 10 kDa interferon-gamma-induced protein （IP-10）in pathological scar and its role in the pathogenesis of pathological scar. Methods Immunohistochemistry was performed to detect the expression and distribution of IP-10 in 28 patients with keloid（group K）,34 patients with hypertrophic scar（group HS）,and 20 normal controls（group N）. The data were collected and analyzed statistically. Results The expression of IP-10 was significantly higher in groups K and HS than in group N （P 0.01）, but no significant difference in the expression of IP-10 was found between groups K and HS. Conclusion IP-10 may enhance the formation of pathological scar by attracting T lymphocytes and inducing immune/inflammatory response.

关 键 词：γ干扰素诱导蛋白10 瘢痕疙瘩 增生性瘢痕 

分 类 号：R619.6[医药卫生—外科学]