电针对慢性炎症疼痛大鼠下丘脑ENK与脊髓OFQ含量的影响  

Influences of electroacupuncture on content of hypothalamus ENK and spinal OFQ in rats with chronic inflammatory pain

作　　者：王薇钧[1] 卢峻[1] 黄怡然[1] 牛川森[2] 马青[1] 郝红伟[2] 李路明[2] 王君仁[1] 图娅[1] 

机构地区：[1]北京中医药大学,北京100029 [2]清华大学

出　　处：《北京中医药大学学报》2010年第3期196-199,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家863计划资助项目(No.2006AA02Z4E9)

摘　　要：目的观察电针对炎症疼痛大鼠下丘脑脑啡肽(ENK)、脊髓孤啡肽(OFQ)含量的影响,探讨单穴电针治疗慢性炎症疼痛的机制。方法将SD大鼠随机分为4组:正常组、模型组、针刺组、电针组,酶联免疫法检测大鼠下丘脑ENK与脊髓腰段OFQ的含量。结果与正常组比,模型组大鼠下丘脑ENK与脊髓腰段OFQ的含量无明显升高(P>0.05);单侧针刺组下丘脑ENK与脊髓OFQ含量比模型组升高(P<0.01、P<0.05),单侧电针组下丘脑ENK与脊髓OFQ含量比模型组升高(P<0.01、P<0.05)。结论单穴针刺与电针可缓解慢性炎症疼痛,其机制可能是与加强中枢ENK、OFQ的合成和释放有关。Objective To observe the influences of electroacupuncture on the content of hypothalamus enkephalin（ENK） and spinal orphanin FQ（OFQ） in rats with chronic inflammatory pain,and investigate the mechanism of electroacupuncture in single acupoint in the treatment of chronic inflammatory pain. Method All SD rats were randomly divided into the normal group,model group,acupuncture group,and electroacupuncture group.The content of hypothalamus ENK and spinal OFQ were detected by using enzyme-linked immunosorbent assay（ELISA）.Result In the model group the content of hypothalamus ENK and spinal OFQ did not increase（P〉0.05） compared with those in the normal group,and those increased respectively in the acupuncture group（P〈0.01,P〈0.05） and the electroacupuncture group （P〈0.01,P〈0.05） compared with those in the model group.Conclusion Acupuncture and electroacupuncture in single acupoint can relieve chronic inflammatory pain,and the mechanism may be related to the improvement of ENK and OFQ synthesis and release in central nervous system.

关 键 词：炎症疼痛 电针 脑啡肽 孤啡肽 大鼠 

分 类 号：R246.9[医药卫生—针灸推拿学]