静电纺聚合物纳米纤维在骨组织工程研究中的进展  

Progresses in the application of electrospun polymer nanofibers in bone tissue engineering

作　　者：罗伟[1] 金旻[1] 罗凤涛[1] 陈林[1] 

机构地区：[1]解放军第三军医大学大坪医院野战外科研究所全军战创伤中心创伤、烧伤与复合伤国家重点实验室,重庆400042

出　　处：《国际生物医学工程杂志》2010年第1期44-49,共6页International Journal of Biomedical Engineering

基　　金：基金项目：国家自然科学基金重点资助项目（30530410）;国家重点基础研究发展规划项目（2005CB522604）;国家自然基金杰出青年基金项目（30425023）

摘　　要：组织工程骨在骨缺损、骨不连及骨折延期愈合等骨骼疾病的治疗中有重要应用前景，、组织工程支架是组织工程研究的核心内容之一，静电纺丝制备的纳米纤维以其优异的性能，近年来已开始成为骨组织支架材料的重要研究对象。综述了静电纺聚合物纳米材料包括天然高分子聚合物、人工合成聚合物及复合聚合物纺丝纤维在骨组织工程研究中的进展，提出复合聚合物电纺纤维及其改性是今后骨组织工程支架材料研究的重要方向之一；并探讨了其研究中存在的问题与应用前景。Bone tissue engineering has potential prospects in treating bone diseases, such as bone defect, bone non-union and delayed healing of bone fracture. The key issue of tissue engineering research is tissue engi- neering scaffold. Recently, studies on bone tissue scaffold material began to pay great attention to eleetrospinning nanofibers, due to its excellent performance. In this review, progresses in exploring the fabrication and applica- tion of electrospun polymer nanofibers including natural polymer, synthetic polymer and composite polymer nanofibers were introduced. We propose that eleetrospun integrated polymer nanofibers and their modification is one of the important future directions in bone tissue engineering scaffold. We also analyze the existed problem and the potential application of electrospun polymer nanofiber-based bone tissue engineering scaffold.

关 键 词：静电纺丝 纳米纤维 骨组织工程 支架 聚合物 

分 类 号：R6[医药卫生—外科学] R3[医药卫生—临床医学]